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In silico study of some bioactive compounds of Pleurotus sajor-caju as antidiabetic and antiviral agents

Das, Dipika ; Dutta, Goutam ; Jahnavi, Jangala ; Patra, Priya ; Bhuniya, Oitrika ; Ramlal, Ayyagari ; Samanta, Aveek

Nutrire, 2024-02, Vol.49 (1), p.17, Article 17 [Periódico revisado por pares]

Cham: Springer International Publishing

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  • Título:
    In silico study of some bioactive compounds of Pleurotus sajor-caju as antidiabetic and antiviral agents
  • Autor: Das, Dipika ; Dutta, Goutam ; Jahnavi, Jangala ; Patra, Priya ; Bhuniya, Oitrika ; Ramlal, Ayyagari ; Samanta, Aveek
  • Assuntos: Antidiabetics ; Antiviral drugs ; Biological activity ; Clinical Nutrition ; Food Science ; Insulin ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Mushrooms ; Nutrition
  • É parte de: Nutrire, 2024-02, Vol.49 (1), p.17, Article 17
  • Descrição: The mushrooms are highly nutritious and have numerous physiological properties and are beneficial due to their medicinal value. Several clinical studies showed the antidiabetic and antimicrobial roles of edible mushrooms. The study of the affinity of the bioactive molecules obtained from edible mushrooms with the insulin receptors is important in this context. The bioactive compounds of Pleurotus sajor-caju , an edible mushroom have been used for the present study. In this study, the molecular basis for selective affinity for the insulin receptor (1GAG) and the major histocompatibility (MHC) class 1 protein (1CE6) with some bioactive molecules namely C 22 H 34 O 4 :10, 12-Docasadiyndioic acid; C 14 H 17 O 9 N, tetraacetyl-D-xylonic nitrile; C 16 H 32 O 2 , N-hexadecanoic acid; C 17 H 34 O, 2-methylhexadecanal; C 18 H 32 O 2 , 9,12-octadecadienoic acid obtained from P. sajor-caju have been studied by using in silico molecular docking approaches. The results show the selected bioactive molecules have the potential ability to bind with insulin receptor (1GAG) and MHC class 1 protein with different affinity. From the present observations, it can be concluded that these compounds could be novel antidiabetic and antiviral agents.
  • Editor: Cham: Springer International Publishing
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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