Idioma:

Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3

Samarghandian, Saeed ; Afshari, Jalil Tavakkol ; Davoodi, Saeideh

Clinics (São Paulo, Brazil), 2011-01, Vol.66 (6), p.1073-1079 [Periódico revisado por pares]

United States: Elsevier España, S.L.U

Texto completo disponível

Citações Citado por

Enviar para

Título:
Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3
Autor: Samarghandian, Saeed ; Afshari, Jalil Tavakkol ; Davoodi, Saeideh
Assuntos: Analysis of Variance ; Annexin A5 - analysis ; Antioxidants - analysis ; Antioxidants - pharmacology ; Apitherapy - methods ; Apoptosis ; Apoptosis - drug effects ; Basic Research ; Carcinoma - prevention & control ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Chrysin ; Cytotoxicity ; Flavonoids - analysis ; Flavonoids - pharmacology ; Flow Cytometry ; Honey ; Humans ; Male ; MEDICINE, GENERAL & INTERNAL ; PC-3 ; Prostatic Neoplasms - prevention & control ; Time Factors
É parte de: Clinics (São Paulo, Brazil), 2011-01, Vol.66 (6), p.1073-1079
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Honey is a common household product with many medicinal uses described in traditional medicine. Only recently has its antioxidant properties and preventive effects against disease been highlighted. Chrysin is a natural flavone commonly found in honey that has been shown to be an antioxidant agent. In this study, we investigated the antiproliferative and apoptotic effects of honey and chrysin on cultured human prostate cancer cells. Cells were cultured in RPMI medium and treated with different concentrations of honey and chrysin for three consecutive days. Cell viability was quantitated by the 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. The percentage of apoptotic cells was determined by flow cytometry using Annexin V-fluorescein isothiocyanate. The MTT assay revealed that both compounds had an antiproliferative effect on PC-3 cells in a dose- and time-dependent manner. The IC50 values for honey and chrysin against PC-3 cells were 2.5% and 24.5% after 48 h and 1.8% and 8.5% after 72 h, respectively. Chrysin induced apoptosis in PC-3 cells, as determined by flow cytometry. Our results suggest that honey has anti-proliferative effects on prostate cancer cells and the effects are mainly due to chrysin. Therefore, chrysin may be a potential compound for both cancer prevention and treatment. Further in vivo investigation is needed to support the use of chrysin in cancer therapy.
Editor: United States: Elsevier España, S.L.U
Idioma: Inglês;Português

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 9 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3

Samarghandian, Saeed ; Afshari, Jalil Tavakkol ; Davoodi, Saeideh

United States: Elsevier España, S.L.U

Buscando em bases de dados remotas. Favor aguardar.