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Differences in the regulation of inflammatory pathways in adolescent- and adult-onset first-episode psychosis

Moreno, C. ; Parellada, M. ; MacDowell, K. S. ; García-Bueno, B. ; Cabrera, B. ; González-Pinto, A. ; Saiz, P. ; Lobo, A. ; Rodriguez-Jimenez, R. ; Berrocoso, E. ; Bernardo, M. ; Leza, J. C.

European child & adolescent psychiatry, 2019-10, Vol.28 (10), p.1395-1405 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
Differences in the regulation of inflammatory pathways in adolescent- and adult-onset first-episode psychosis
Autor: Moreno, C. ; Parellada, M. ; MacDowell, K. S. ; García-Bueno, B. ; Cabrera, B. ; González-Pinto, A. ; Saiz, P. ; Lobo, A. ; Rodriguez-Jimenez, R. ; Berrocoso, E. ; Bernardo, M. ; Leza, J. C.
Assuntos: Adolescent ; Adolescents ; Adult ; Adults ; Age ; Age of onset ; Biomarkers - blood ; Blood ; Child ; Child & adolescent psychiatry ; Child and Adolescent Psychiatry ; Cohort Studies ; Female ; First time ; Humans ; Inflammation ; Inflammation - metabolism ; Leukocytes (mononuclear) ; Male ; Medicine ; Medicine & Public Health ; NF-κB protein ; Nitric-oxide synthase ; Nitrogen dioxide ; Original Contribution ; Peripheral blood mononuclear cells ; Prostaglandin E2 ; Psychiatry ; Psychosis ; Psychotic Disorders - etiology ; Teenagers ; Therapeutic applications ; Young Adult
É parte de: European child & adolescent psychiatry, 2019-10, Vol.28 (10), p.1395-1405
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: A precise description of the inflammatory response in first-episode psychosis (FEP) by age of onset does not exist. We explored baseline and 6-month follow-up differences in the pro/anti-inflammatory balance in plasma and peripheral blood mononuclear cells in adolescent-onset FEP (≤ 18 y.o., N = 27) and adult-onset FEP (≥ 25 y.o., N = 43) using non-parametric 1-category ANCOVA, with age group as an independent variable and values of pro- and anti-inflammatory markers at baseline and at follow-up as dependent variables. We used a non-parametric repeated-measures mixed-effects model to explore the baseline/6-month change in pro- and anti-inflammatory markers within adolescent- and adult-onset groups, exploring differential trajectories of change by means of the interaction of time by age-of-onset group. Levels of the nuclear transcription factor (NFκB), a master regulator of the inflammatory and oxido/nitrosative status of cells, were higher in adolescent-onset FEP both at baseline and after 6 months. During follow-up, we found further increases in levels of soluble inflammatory markers (PGE 2 and NO 2 − ) only in adolescent-onset FEP. In contrast, in adult-onset FEP, the expression of inducible NO synthase (iNOS), which is also pro-inflammatory, tended to decrease, with no further increase in other pro-inflammatory markers. Significant differences in the direction of change by age-of-onset cohort exist only for NFκB ( F = 4.165, df = 2, 70.95, p = 0.019). Our results support the existence of changes in the pro/anti-inflammatory balance in FEP depending on the neurodevelopmental stage at illness onset. These results also suggest that inflammation may be a potential therapeutic target in adolescent-onset FEP.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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Differences in the regulation of inflammatory pathways in adolescent- and adult-onset first-episode psychosis

Moreno, C. ; Parellada, M. ; MacDowell, K. S. ; García-Bueno, B. ; Cabrera, B. ; González-Pinto, A. ; Saiz, P. ; Lobo, A. ; Rodriguez-Jimenez, R. ; Berrocoso, E. ; Bernardo, M. ; Leza, J. C.

Berlin/Heidelberg: Springer Berlin Heidelberg

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