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Relationships between Smoking Status, Cardiovascular Risk Factors, and Lipoproteins in a Large Japanese Population

Nakamura, Marie ; Yamamoto, Yasushi ; Imaoka, Wataru ; Kuroshima, Toshio ; Toragai, Ryoko ; Ito, Yasuki ; Kanda, Eiichiro ; Schaefer, Ernst J ; Ai, Masumi

Journal of Atherosclerosis and Thrombosis, 2021/09/01, Vol.28(9), pp.942-953

Japan: Japan Atherosclerosis Society

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Título:
Relationships between Smoking Status, Cardiovascular Risk Factors, and Lipoproteins in a Large Japanese Population
Autor: Nakamura, Marie ; Yamamoto, Yasushi ; Imaoka, Wataru ; Kuroshima, Toshio ; Toragai, Ryoko ; Ito, Yasuki ; Kanda, Eiichiro ; Schaefer, Ernst J ; Ai, Masumi
Assuntos: Cardiovascular disease risk ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - etiology ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cigarette Smoking - adverse effects ; Cigarette Smoking - blood ; Dyslipidemia ; Female ; Heart Disease Risk Factors ; Humans ; Japan - epidemiology ; Male ; Middle Aged ; Original ; Small dense LDL-C ; Smoking ; Smoking cessation ; Triglycerides - blood
É parte de: Journal of Atherosclerosis and Thrombosis, 2021/09/01, Vol.28(9), pp.942-953
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Aims: Smoking is a major risk factor for cardiovascular disease (CVD), a leading cause of death and disability. Other CVD risk factors include age, gender, hypertension, diabetes, increased low-density lipoprotein cholesterol (LDL-C) and decreased high-density lipoprotein cholesterol (HDL-C). Our goal was to assess relationships between smoking status and CVD risk factors, with a focus on direct LDL-C, HDL-C, triglycerides (TG) and small dense LDL-C (sdLDL-C). Methods: A total of 34,497 Japanese men and women, mean age 51 years, had their CVD risk factors including fasting serum total cholesterol, TG, HDL-C, sdLDL-C, and direct LDL-C assessed. One-way ANOVA and multiple linear regression analyses were carried to assess the interrelationships of these parameters with smoking. Results: In both men and women, current smokers had significantly (p＜0.001) higher median TG (+19.6%, +16.9%) and sdLDL-C levels (+12.7%, +4.2%) levels, and significantly (p＜0.001) lower HDL-C levels (-7.3%, -4.3%) than non-smokers. They were also significantly (p＜0.05) more likely to have TG values ＞150 mg/dL (+56.8%, +116.3%), sdLDL-C ＞40.1 mg/dL (+28.8%, +44.9%), and HDL-C ＜40 mg/dL (+89.8%, +114.3%). Ex-smokers generally had lipid values that were intermediate between non-smokers and current smokers. Multivariate analysis confirmed the significance of these relationships. Conclusion: Our data indicate that current cigarette smoking is associated with increased TG and sdLDL-C levels, as well as decreased HDL-C levels. Furthermore, smoking effect on lipid profiles remain after cessation. These data provide further justification for smoking cessation.
Editor: Japan: Japan Atherosclerosis Society
Idioma: Inglês;Japonês

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Relationships between Smoking Status, Cardiovascular Risk Factors, and Lipoproteins in a Large Japanese Population

Nakamura, Marie ; Yamamoto, Yasushi ; Imaoka, Wataru ; Kuroshima, Toshio ; Toragai, Ryoko ; Ito, Yasuki ; Kanda, Eiichiro ; Schaefer, Ernst J ; Ai, Masumi

Japan: Japan Atherosclerosis Society

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