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Risk of rupture of unruptured cerebral aneurysms in elderly patients

Hishikawa, Tomohito ; Date, Isao ; Tokunaga, Koji ; Tominari, Shinjiro ; Nozaki, Kazuhiko ; Shiokawa, Yoshiaki ; Houkin, Kiyohiro ; Murayama, Yuichi ; Ishibashi, Toshihiro ; Takao, Hiroyuki ; Kimura, Toshikazu ; Nakayama, Takeo ; Morita, Akio

Neurology, 2015-11, Vol.85 (21), p.1879-1885 [Periódico revisado por pares]

United States: American Academy of Neurology

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  • Título:
    Risk of rupture of unruptured cerebral aneurysms in elderly patients
  • Autor: Hishikawa, Tomohito ; Date, Isao ; Tokunaga, Koji ; Tominari, Shinjiro ; Nozaki, Kazuhiko ; Shiokawa, Yoshiaki ; Houkin, Kiyohiro ; Murayama, Yuichi ; Ishibashi, Toshihiro ; Takao, Hiroyuki ; Kimura, Toshikazu ; Nakayama, Takeo ; Morita, Akio
  • Assuntos: Age Factors ; Aged ; Aged, 80 and over ; Aneurysm, Ruptured - diagnosis ; Aneurysm, Ruptured - epidemiology ; Female ; Humans ; Intracranial Aneurysm - diagnosis ; Intracranial Aneurysm - epidemiology ; Japan - epidemiology ; Male ; Prospective Studies ; Risk Factors
  • É parte de: Neurology, 2015-11, Vol.85 (21), p.1879-1885
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
    The Article Processing Charge was paid by Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
    UCAS Japan and UCAS II coinvestigators are listed on the Neurology® Web site at Neurology.org.
  • Descrição: OBJECTIVES:The aim of this study was to identify risk factors for rupture of unruptured cerebral aneurysms (UCAs) in elderly Japanese patients aged 70 years or older. METHODS:The participants included all patients 70 years of age or older in 3 prospective studies in Japan (the Unruptured Cerebral Aneurysm Study of Japan [UCAS Japan], UCAS II, and the prospective study at the Jikei University School of Medicine). A total of 1,896 patients aged 70 years or older with 2,227 UCAs were investigated. The median and mean follow-up periods were 990 and 802.7 days, respectively. RESULTS:The mean aneurysm size was 6.2 ± 3.9 mm. Sixty-eight patients (3.6%) experienced subarachnoid hemorrhage during the follow-up period. Multivariable analysis per patient revealed that in patients aged 80 years or older (hazard ratio [HR], 2.02; 95% confidence interval [CI], 1.16–3.49, p = 0.012), aneurysms 7 mm or larger (HR, 3.08; 95% CI, 1.35–7.03, p = 0.007 for 7–9 mm; HR, 7.82; 95% CI, 3.60–16.98, p < 0.001 for 10–24 mm; and HR, 43.31; 95% CI, 12.55–149.42, p < 0.001 for ≥25 mm) and internal carotid–posterior communicating artery aneurysms (HR, 2.45; 95% CI, 1.23–4.88, p = 0.011) were independent predictors for UCA rupture in elderly patients. CONCLUSIONS:In our pooled analysis of prospective cohorts in Japan, patient age and aneurysm size and location were significant risk factors for UCA rupture in elderly patients.
  • Editor: United States: American Academy of Neurology
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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