skip to main content
Visitante
Meu Espaço
Minha Conta
Sair
Identificação
This feature requires javascript
Tags
Revistas Eletrônicas (eJournals)
Livros Eletrônicos (eBooks)
Bases de Dados
Bibliotecas USP
Ajuda
Ajuda
Idioma:
Inglês
Espanhol
Português
This feature required javascript
This feature requires javascript
Primo Search
Busca Geral
Busca Geral
Acervo Físico
Acervo Físico
Produção Intelectual da USP
Produção USP
Search For:
Clear Search Box
Search in:
Busca Geral
Or hit Enter to replace search target
Or select another collection:
Search in:
Busca Geral
Busca Avançada
Busca por Índices
This feature requires javascript
This feature requires javascript
Engineering Cellular Metabolism
Nielsen, Jens ; Keasling, Jay D.
Cell, 2016-03, Vol.164 (6), p.1185-1197
[Periódico revisado por pares]
United States: Elsevier Inc
Texto completo disponível
Citações
Citado por
Exibir Online
Detalhes
Resenhas & Tags
Mais Opções
Nº de Citações
This feature requires javascript
Enviar para
Adicionar ao Meu Espaço
Remover do Meu Espaço
E-mail (máximo 30 registros por vez)
Imprimir
Link permanente
Referência
EasyBib
EndNote
RefWorks
del.icio.us
Exportar RIS
Exportar BibTeX
This feature requires javascript
Título:
Engineering Cellular Metabolism
Autor:
Nielsen, Jens
;
Keasling, Jay D.
Assuntos:
acetyl-coa metabolism
;
Animals
;
Bacteria - classification
;
Bacteria - metabolism
;
Biochemistry & Molecular Biology
;
Biological Products - metabolism
;
Biosynthetic Pathways
;
Cell Biology
;
cell factories
;
CHO Cells
;
Cricetulus
;
de-novo production
;
Drug Discovery
;
Escherichia coli - metabolism
;
escherichia-coli
;
Fungi - classification
;
Fungi - metabolism
;
gene-expression
;
genome-scale models
;
high-level production
;
industrial biotechnology
;
Industrial Microbiology - methods
;
Metabolic Engineering
;
metabolism
;
optimization
;
pathway
;
regulation
;
regulatory network
;
Saccharomyces cerevisiae - metabolism
;
saccharomyces-cerevisiae
;
synthetic biology
É parte de:
Cell, 2016-03, Vol.164 (6), p.1185-1197
Notas:
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
AC02-05CH11231
USDOE Office of Science (SC), Biological and Environmental Research (BER)
Descrição:
Metabolic engineering is the science of rewiring the metabolism of cells to enhance production of native metabolites or to endow cells with the ability to produce new products. The potential applications of such efforts are wide ranging, including the generation of fuels, chemicals, foods, feeds, and pharmaceuticals. However, making cells into efficient factories is challenging because cells have evolved robust metabolic networks with hard-wired, tightly regulated lines of communication between molecular pathways that resist efforts to divert resources. Here, we will review the current status and challenges of metabolic engineering and will discuss how new technologies can enable metabolic engineering to be scaled up to the industrial level, either by cutting off the lines of control for endogenous metabolism or by infiltrating the system with disruptive, heterologous pathways that overcome cellular regulation. Making cells into factories that churn out desired molecular products is challenging because metabolic networks have evolved to resist disruption, and requires hacking into cellular metabolism to rewire these lines of communication.
Editor:
United States: Elsevier Inc
Idioma:
Inglês
Links
View this record in MEDLINE/PubMed
View this record in Osti.gov
View record from Swedish Publication Index
View record from Swedish Publication Index
This feature requires javascript
This feature requires javascript
Voltar para lista de resultados
Anterior
Resultado
3
Avançar
This feature requires javascript
This feature requires javascript
Buscando em bases de dados remotas. Favor aguardar.
Buscando por
em
scope:(USP_VIDEOS),scope:("PRIMO"),scope:(USP_FISICO),scope:(USP_EREVISTAS),scope:(USP),scope:(USP_EBOOKS),scope:(USP_PRODUCAO),primo_central_multiple_fe
Mostrar o que foi encontrado até o momento
This feature requires javascript
This feature requires javascript