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Macrophage Activation by an Acidic Polysaccharide Isolated from Angelica Sinensis (Oliv.) Diels

Yang, Xingbin (Shaanxi Normal University, Xi'an, China), E-mail: xbyang@snnu.edu.cn ; Zhao, Yan (Fourth Military Medical University, Xi'an, China) ; Wang, Haifang (Fourth Military Medical University, Xi'an, China) ; Mei, Qibing (Fourth Military Medical University, Xi'an, China), E-mail: qbmei@fmmu.edu.cn

BMB reports, 2007-09, Vol.40 (5), p.636-643 [Periódico revisado por pares]

Korea (South)

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Título:
Macrophage Activation by an Acidic Polysaccharide Isolated from Angelica Sinensis (Oliv.) Diels
Autor: Yang, Xingbin (Shaanxi Normal University, Xi'an, China), E-mail: xbyang@snnu.edu.cn ; Zhao, Yan (Fourth Military Medical University, Xi'an, China) ; Wang, Haifang (Fourth Military Medical University, Xi'an, China) ; Mei, Qibing (Fourth Military Medical University, Xi'an, China), E-mail: qbmei@fmmu.edu.cn
Assuntos: angelica polysaccharide ; Angelica sinensis - chemistry ; Animals ; Cell Line ; Cell Survival - drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Female ; Gene Expression Regulation, Enzymologic - drug effects ; LIPOPOLISACARIDOS ; LIPOPOLYSACCHARIDE ; LIPOPOLYSACCHARIDES ; Lysosomes - drug effects ; Lysosomes - enzymology ; Macrophage Activation - drug effects ; Macrophages, Peritoneal - cytology ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - metabolism ; Mice ; Mice, Inbred BALB C ; NG-Nitroarginine Methyl Ester - pharmacology ; NITRIC OXIDE ; Nitric Oxide - metabolism ; Nitric Oxide Synthase Type II - antagonists & inhibitors ; Nitric Oxide Synthase Type II - genetics ; Nitric Oxide Synthase Type II - metabolism ; OXIDO NITRICO ; OXYDE NITRIQUE ; peritoneal macrophage ; Plant Extracts - pharmacology ; Plant Roots - chemistry ; Polysaccharides - chemistry ; Polysaccharides - isolation & purification ; Polysaccharides - pharmacology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; toll-like receptor 4 ; Toll-Like Receptor 4 - metabolism ; Tumor Necrosis Factor-alpha - metabolism
É parte de: BMB reports, 2007-09, Vol.40 (5), p.636-643
Notas: A50
2008000666
Descrição: This study was designed to identify and characterize the mechanism of macrophage activation by AAP, an acidic polysaccharide fraction isolated from the roots of Angelica sinensis (Oliv.) Diels. As a result, AAP significantly enhanced nitric oxide (NO) production and cellular lysosomal enzyme activity in murine peritoneal macrophages in vitro and in vivo. Furthermore, L-NAME, a specific inhibitor of inducible nitric oxide synthase (iNOS), effectively suppressed AAP-induced NO generation in macrophages, indicating that AAP stimulated macrophages to produce NO through the induction of iNOS gene expression and the result was further confirmed by the experiment of the increase of AAP-induced iNOS transcription in a dose-dependent manner.
Editor: Korea (South)
Idioma: Inglês

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Macrophage Activation by an Acidic Polysaccharide Isolated from Angelica Sinensis (Oliv.) Diels

Korea (South)

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