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Wound Macrophages as Key Regulators of Repair: Origin, Phenotype, and Function

BRANCATO, Samielle K ; ALBINA, Jorge E

The American journal of pathology, 2011, Vol.178 (1), p.19-25 [Periódico revisado por pares]

Bethesda, MD: American Society for Investigative Pathology

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Título:
Wound Macrophages as Key Regulators of Repair: Origin, Phenotype, and Function
Autor: BRANCATO, Samielle K ; ALBINA, Jorge E
Assuntos: Animals ; Biological and medical sciences ; Fibrosis ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Macrophages - physiology ; Medical sciences ; Mice ; Mini-Review ; Neovascularization, Physiologic ; Neutrophils - physiology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Transforming Growth Factor beta - physiology ; Vascular Endothelial Growth Factor A - physiology ; Wound Healing - physiology ; Wounds and Injuries - pathology ; Wounds and Injuries - physiopathology
É parte de: The American journal of pathology, 2011, Vol.178 (1), p.19-25
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Recent results call for the reexamination of the phenotype of wound macrophages and their role in tissue repair. These results include the characterization of distinct circulating monocyte populations with temporally restricted capacities to migrate into wounds and the observation that the phenotype of macrophages isolated from murine wounds partially reflects those of their precursor monocytes, changes with time, and does not conform to current macrophage classifications. Moreover, findings in genetically modified mice lacking macrophages have confirmed that these cells are essential to normal wound healing because their depletion results in retarded and abnormal repair. This mini-review focuses on current knowledge of the phenotype of wound macrophages, their origin and fate, and the specific macrophage functions that underlie their reparative role in injured tissues, including the regulation of the cellular infiltration of the wound and the production of transforming growth factor-β and vascular endothelial growth factor.
Editor: Bethesda, MD: American Society for Investigative Pathology
Idioma: Inglês

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Wound Macrophages as Key Regulators of Repair: Origin, Phenotype, and Function

BRANCATO, Samielle K ; ALBINA, Jorge E

Bethesda, MD: American Society for Investigative Pathology

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