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Cumulative live birth rates between GnRH-agonist long and GnRH-antagonist protocol in one ART cycle when all embryos transferred: real-word data of 18,853 women from China

Yang, Jingwei ; Zhang, Xiaodong ; Ding, Xiaoyan ; Wang, Yuting ; Huang, Guoning ; Ye, Hong

Reproductive biology and endocrinology, 2021-08, Vol.19 (1), p.124-124, Article 124 [Periódico revisado por pares]

England: BioMed Central Ltd

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Cumulative live birth rates between GnRH-agonist long and GnRH-antagonist protocol in one ART cycle when all embryos transferred: real-word data of 18,853 women from China
Autor: Yang, Jingwei ; Zhang, Xiaodong ; Ding, Xiaoyan ; Wang, Yuting ; Huang, Guoning ; Ye, Hong
Assuntos: Adult ; Agonists ; ART cycle ; Birth rate ; China ; Chorionic Gonadotropin - therapeutic use ; Clinical trials ; Comparative analysis ; Cryopreservation ; Cumulative live birth rate ; Embryo transfer ; Embryo Transfer - methods ; Embryonic development ; Embryos ; Estrogens ; Female ; Fertility Agents, Female - therapeutic use ; Fertilization ; Fertilization in Vitro - methods ; Follicle Stimulating Hormone - therapeutic use ; Gonadotropin releasing hormone agonist long protocol ; Gonadotropin releasing hormone antagonist protocol ; Gonadotropin-releasing hormone ; Gonadotropin-Releasing Hormone - agonists ; Gonadotropin-Releasing Hormone - analogs & derivatives ; Gonadotropin-Releasing Hormone - antagonists & inhibitors ; Gonadotropin-Releasing Hormone - therapeutic use ; Hormone antagonists ; Hormone Antagonists - therapeutic use ; Hormones - therapeutic use ; Humans ; In vitro fertilization ; Infertility ; Logistic Models ; Multivariate Analysis ; Neurohormones ; Ovaries ; Ovulation Induction - methods ; Patients ; Pregnancy ; Pregnancy Rate ; Recombinant Proteins - therapeutic use ; Reproductive technology ; Sucrose ; Treatment Outcome ; Triptorelin Pamoate - therapeutic use ; Vagina ; Womens health
É parte de: Reproductive biology and endocrinology, 2021-08, Vol.19 (1), p.124-124, Article 124
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: A consensus has been reached on the preferred primary outcome of all infertility treatment trials, which is the cumulative live birth rate (CLBR). Some recent randomized controlled trials (RCTs) and retrospective studies have compared the effectiveness of GnRH-antagonist and GnRH-agonist protocols but showed inconsistent results. Studies commonly used conservative estimates and optimal estimates to described the CLBR of one incomplete assisted reproductive technology (ART) cycle and there are not many previous studies with data of the complete cycle to compare CLBRs in GnRH-antagonist versus GnRH-agonist protocols. A total of 18,853 patients have completed their first IVF cycle including fresh and subsequent frozen-thawed cycles during 2016-2019, 16,827 patients were treated with GnRH-a long and 2026 patients with GnRH-ant protocol. Multivariable logistic analysis was used to evaluate the difference of GnRH-a and GnRH-ant protocol in relation to CLBR. Utilized Propensity Score Matching(PSM) for sampling by up to 1:1 nearest neighbor matching to adjust the numerical difference and balance the confounders between groups. Before PSM, significant differences were observed in baseline characteristics and the CLBR was 50.91% in the GnRH-a and 33.42% in the GnRH-ant (OR = 2.07; 95%CI: 1.88-2.28; P < 0.001). Stratified analysis showed the CLBR of GnRH-ant was lower than GnRH-a in suboptimal responders(46.89 vs 27.42%, OR = 2.34, 95%CI = 1.99-2.74; P < 0.001) and no differences of CLBR were observed in other patients between protocols. After adjusting for potential confounders, multivariable logistic analysis found the CLBR of GnRH-ant group was lower than that of GnRH-a group (OR = 2.11, 95%CI:1.69-2.63, P < 0.001). After PSM balenced the confounders between groups, the CLBR of GnRH-a group was higher than that of GnRH-ant group in suboptimal responders((38.61 vs 28.22%, OR = 1.60, 95%CI = 1.28-1.99; P < 0.001) and the normal fertilization rate and number of available embryo in GnRH-a were higher than these of GnRH-ant groups in suboptimal responders (77.39 vs 75.22%; 2.86 ± 1.26 vs 2.61 ± 1.22; P < 0.05). No significant difference was observed in other patients between different protocols. It is crucial to optimize the utilization of protocols in different ovarian response patients and reconsider the field of application of GnRH-ant protocols in China.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Cumulative live birth rates between GnRH-agonist long and GnRH-antagonist protocol in one ART cycle when all embryos transferred: real-word data of 18,853 women from China

Yang, Jingwei ; Zhang, Xiaodong ; Ding, Xiaoyan ; Wang, Yuting ; Huang, Guoning ; Ye, Hong

England: BioMed Central Ltd

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