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Different Approaches to Modulation of Microglia Phenotypes After Spinal Cord Injury

Akhmetzyanova, Elvira ; Kletenkov, Konstantin ; Mukhamedshina, Yana ; Rizvanov, Albert

Frontiers in systems neuroscience, 2019-08, Vol.13, p.37-37 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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  • Título:
    Different Approaches to Modulation of Microglia Phenotypes After Spinal Cord Injury
  • Autor: Akhmetzyanova, Elvira ; Kletenkov, Konstantin ; Mukhamedshina, Yana ; Rizvanov, Albert
  • Assuntos: microglia ; modulation ; neuroregeneration ; Neuroscience ; phenotypes ; spinal cord injury
  • É parte de: Frontiers in systems neuroscience, 2019-08, Vol.13, p.37-37
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    Reviewed by: John Gensel, University of Kentucky, United States; Michelle Hook, Texas A&M University, United States
    Edited by: Preston E. Garraghty, Indiana University Bloomington, United States
  • Descrição: Microglial cells, which are highly plastic, immediately respond to any change in the microenvironment by becoming activated and shifting the phenotype toward neurotoxicity or neuroprotection. The polarization of microglia/macrophages after spinal cord injury (SCI) seems to be a dynamic process and can change depending on the microenvironment, stage, course, and severity of the posttraumatic process. Effective methods to modulate microglia toward a neuroprotective phenotype in order to stimulate neuroregeneration are actively sought for. In this context, available approaches that can selectively impact the polarization of microglia/macrophages regulate synthesis of trophic factors and cytokines/chemokines in them, and their phagocytic function and effects on the course and outcome of SCI are discussed in this review.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
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