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Endothelial Progenitor Cells Correlated with Oxidative Stress after Mild Traumatic Brain Injury

Huang, Xintao ; Wan, Dahai ; Lin, Yunpeng ; Xue, Naizhao ; Hao, Jiehe ; Ma, Ning ; Pei, Xile ; Li, Ruilong ; Zhang, Wenju

Yonsei Medical Journal, 2017, 58(5), , pp.1012-1017 [Periódico revisado por pares]

Korea (South): 연세대학교의과대학

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  • Título:
    Endothelial Progenitor Cells Correlated with Oxidative Stress after Mild Traumatic Brain Injury
  • Autor: Huang, Xintao ; Wan, Dahai ; Lin, Yunpeng ; Xue, Naizhao ; Hao, Jiehe ; Ma, Ning ; Pei, Xile ; Li, Ruilong ; Zhang, Wenju
  • Assuntos: Adult ; Aged ; Aged, 80 and over ; Animals ; Brain Injuries, Traumatic - enzymology ; Brain Injuries, Traumatic - pathology ; Cell Count ; Demography ; Endothelial Progenitor Cells - pathology ; Female ; Humans ; Male ; Malondialdehyde - metabolism ; Middle Aged ; Original ; Oxidative Stress ; Superoxide Dismutase - metabolism ; Young Adult ; 의학일반
  • É parte de: Yonsei Medical Journal, 2017, 58(5), , pp.1012-1017
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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    Xintao Huang and Dahai Wan contributed equally to this work.
    https://www.eymj.org/DOIx.php?id=10.3349/ymj.2017.58.5.1012
  • Descrição: Endothelial progenitor cells (EPCs) play a key role in tissue repair and regeneration. Previous studies have shown that infusion of human umbilical cord blood-derived endothelial colony-forming cells improves outcomes in mice subjected to experimental traumatic brain injury (TBI). However, the efficiency of cell transplantation is not satisfactory. Oxidative stress plays a significant role in the survival of transplanted cells following ischemic reperfusion injury. This observational clinical study investigated the correlation between the number of circulating EPCs and plasma levels of superoxide dismutase (SOD) and malonyldialdehyde (MDA). Peripheral blood samples were collected from 20 patients with mild TBI at day-1, day-2, day-3, day-4, and day-7 post TBI. The number of circulating EPCs and the plasma levels of SOD and MDA were measured. The average of circulating EPCs in TBI patients decreased initially, but increased thereafter, compared with healthy controls. Plasma levels of SOD in TBI patients were significantly lower than those in healthy controls at day-4 post-TBI. MDA levels showed no difference between the two groups. Furthermore, when assessed on day-7 post-TBI, the circulating EPC number were correlated with the plasma levels of SOD and MDA. These results suggest that the number of circulating EPCs is weakly to moderately correlated with plasma levels of SOD and MDA at day-7 post-TBI, which may offer a novel antioxidant strategy for EPCs transplantation after TBI.
  • Editor: Korea (South): 연세대학교의과대학
  • Idioma: Coreano;Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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