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Vitamin E supplementation inhibits muscle damage and inflammation after moderate exercise in hypoxia

Santos, S. A. ; Silva, E. T. ; Caris, A. V. ; Lira, F. S. ; Tufik, S. ; dos Santos, R. V. T.

Journal of human nutrition and dietetics, 2016-08, Vol.29 (4), p.516-522 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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Título:
Vitamin E supplementation inhibits muscle damage and inflammation after moderate exercise in hypoxia
Autor: Santos, S. A. ; Silva, E. T. ; Caris, A. V. ; Lira, F. S. ; Tufik, S. ; dos Santos, R. V. T.
Assuntos: Adult ; altitude ; Altitude Sickness - physiopathology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Antioxidants - therapeutic use ; Atmosphere Exposure Chambers ; Biomarkers - blood ; cellular damage ; Creatine ; Creatine kinase ; Damage ; Dietary Supplements ; Double-Blind Method ; Exercise ; Hemoglobin ; Humans ; Hypoxia ; Inflammation ; Interleukins ; Kinases ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lactic acid ; Male ; Muscle, Skeletal - immunology ; Muscle, Skeletal - physiopathology ; Muscles ; Myositis - etiology ; Myositis - immunology ; Myositis - prevention & control ; Oxidative Stress ; Oxygen Consumption ; Oxygen content ; Oxygen uptake ; Parameters ; physical exercise ; Running ; Sports Nutritional Physiological Phenomena ; supplementation ; Supplements ; Time Factors ; Tocopherol ; Tumor necrosis factor ; Tumor necrosis factor-TNF ; Tumors ; Vitamin E ; Vitamin E - therapeutic use ; Young Adult
É parte de: Journal of human nutrition and dietetics, 2016-08, Vol.29 (4), p.516-522
Notas: Associação Fundo de Incentivo á Psicofarmacologia (AFIP)
ArticleID:JHN12361
Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP) - No. 2011/10917
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
istex:DB5EEA579C7453B0469B2E7410FC7460C94FA78F
ark:/67375/WNG-4V12N478-V
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Descrição: Background Exercise under hypoxic conditions represents an additional stress in relation to exercise in normoxia. Hypoxia induces oxidative stress and inflammation as mediated through tumour necrosis factor (TNF)‐α release that might be exacerbated through exercise. In addition, vitamin E supplementation might attenuate oxidative stress and inflammation resulting from hypoxia during exercise. The present study aimed to evaluate the effects of vitamin E supplementation (250 mg) on inflammatory parameters and cellular damage after exercise under hypoxia simulating an altitude of 4200 m. Methods Nine volunteers performed three sessions of 60 min of exercise (70% maximal oxygen uptake) interspersed for 1 week under normoxia, hypoxia and hypoxia after vitamin E supplementation 1 h before exercise. Blood was collected before, immediately after and at 1 h after exercise to measure inflammatory parameters and cell damage. Results Percentage oxygen saturation of haemoglobin decreased after exercise and recovered 1 h later in the hypoxia + vitamin condition (P < 0.05). Supplementation decreased creatine kinase (CK)‐TOTAL, CK‐MB and lactate dehydrogenase 1 h after exercise (P < 0.05). The exercise in hypoxia increased interleukin (IL)‐6, TNF‐α, IL‐1ra and IL‐10 immediately after exercise (P < 0.05). Supplementation reversed the changes observed after exercise in hypoxia without supplementation (P < 0.05). Conclusions We conclude that 250 mg of vitamin E supplementation at 1 h before exercise reduces cell damage markers after exercise in hypoxia and changes the concentration of cytokines, suggesting a possible protective effect against inflammation induced by hypoxia during exercise.
Editor: England: Blackwell Publishing Ltd
Idioma: Inglês

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Vitamin E supplementation inhibits muscle damage and inflammation after moderate exercise in hypoxia

Santos, S. A. ; Silva, E. T. ; Caris, A. V. ; Lira, F. S. ; Tufik, S. ; dos Santos, R. V. T.

England: Blackwell Publishing Ltd

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