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Autoradiographic analysis of 125I-substance P binding in rat spinal cord following chronic constriction injury of the sciatic nerve

Aanonsen, L.M. ; Kajander, K.C. ; Bennett, G.J. ; Seybold, V.S.

Brain research, 1992-11, Vol.596 (1), p.259-268 [Periódico revisado por pares]

London: Elsevier B.V

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Título:
Autoradiographic analysis of 125I-substance P binding in rat spinal cord following chronic constriction injury of the sciatic nerve
Autor: Aanonsen, L.M. ; Kajander, K.C. ; Bennett, G.J. ; Seybold, V.S.
Assuntos: Animals ; Autoradiography ; Biological and medical sciences ; Chronic constriction injury Pain ; Chronic Disease ; Constriction, Pathologic - metabolism ; Constriction, Pathologic - physiopathology ; Defense Mechanisms ; Fundamental and applied biological sciences. Psychology ; Hyperalgesia ; Indicators and Reagents ; Iodine Radioisotopes ; Male ; NK 1 receptor ; Rats ; Rats, Sprague-Dawley ; Reaction Time ; Receptor binding ; Sciatic Nerve - injuries ; Sciatic Nerve - physiopathology ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Spinal cord ; Spinal Cord - metabolism ; Substance P ; Substance P - metabolism ; Succinimides ; Vertebrates: nervous system and sense organs ; Wounds, Nonpenetrating - metabolism ; Wounds, Nonpenetrating - physiopathology
É parte de: Brain research, 1992-11, Vol.596 (1), p.259-268
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Using receptor binding and autoradiographic techniques, changes in Bolton-Hunter labeled 125I-substance P ( 125I-BH-SP) binding were determined in laminae I/II, V and X of rat lumbar spinal cord after chronicconstriction injury (CCI) of the sciatic nerve. When compared to the sham-operated side of the control group, SP binding significantly increasedipsilateral to the CCI in laminae I/II at 5, 10 and 20 days after injury and in lamina V at 5 days after injury. Scatchard analysis was performed on the 125I-BH-SP binding to the NK 1 receptor in laminae I/II of rats 5 days after generation of the CCI. A significant decrease in the K d 125I-BH-SP binding was observed in laminae I/II ipsilateral to CCI when compared with the control side (ipsilateral to sham surgery). There was no significant change in the B max in laminae I/II ipsilateral to CCI. The changes in 125I-BH-SP binding in the rat spinal cord that occurred after CCI were found in areas of the spinal cord that receive terminations of nociceptive primary afferent fibers. The increased affinity of the NK 1 binding site that we report could result in an increase in SP receptor activation in laminae I/II. Such central changes in SP binding may contribute to the neuropathic pain syndrome observed in rats with the CCI.
Editor: London: Elsevier B.V
Idioma: Inglês

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Autoradiographic analysis of 125I-substance P binding in rat spinal cord following chronic constriction injury of the sciatic nerve

Aanonsen, L.M. ; Kajander, K.C. ; Bennett, G.J. ; Seybold, V.S.

London: Elsevier B.V

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