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Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep

Guillaume, V ; Magnan, E ; Cataldi, M ; Dutour, A ; Sauze, N ; Renard, M ; Razafindraibe, H ; Conte-Devolx, B ; Deghenghi, R ; Lenaerts, V

Endocrinology (Philadelphia), 1994-09, Vol.135 (3), p.1073-1076 [Periódico revisado por pares]

United States

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Título:
Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep
Autor: Guillaume, V ; Magnan, E ; Cataldi, M ; Dutour, A ; Sauze, N ; Renard, M ; Razafindraibe, H ; Conte-Devolx, B ; Deghenghi, R ; Lenaerts, V
Assuntos: Animals ; Growth Hormone - blood ; Growth Hormone - metabolism ; Growth Hormone-Releasing Hormone - blood ; Growth Hormone-Releasing Hormone - secretion ; Growth Substances - pharmacology ; Male ; Oligopeptides - pharmacology ; Pituitary Gland - blood supply ; Portal System ; Sheep ; Somatostatin - blood
É parte de: Endocrinology (Philadelphia), 1994-09, Vol.135 (3), p.1073-1076
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The acute effect of a new GH-releasing peptide, hexarelin (1 mg, iv), on GH secretion and the mechanisms involved in its changes were investigated in conscious sheep. Peripheral GH levels and GH-releasing hormone (GHRH) and somatostatin concentrations in hypophysial portal blood were measured in six rams. An increase in jugular GH levels was observed 15 min after hexarelin injection (9.1 +/- 1.8 vs. 3.9 +/- 0.8 ng/ml; P < 0.05). This was associated with a stimulation of GHRH release into hypophysial portal blood (145.4 +/- 19.9 vs. 59.2 +/- 10.8 pg/ml; P < 0.01) without a change in somatostatin secretion. Our data indicate that GH-releasing peptide-induced GH stimulation in the sheep involves an activation of GHRH neurons in addition to the previously demonstrated direct effect on the pituitary cells.
Editor: United States
Idioma: Inglês

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Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep

Guillaume, V ; Magnan, E ; Cataldi, M ; Dutour, A ; Sauze, N ; Renard, M ; Razafindraibe, H ; Conte-Devolx, B ; Deghenghi, R ; Lenaerts, V

United States

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