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Amyloid blood biomarker detects Alzheimer's disease

Nabers, Andreas ; Perna, Laura ; Lange, Julia ; Mons, Ute ; Schartner, Jonas ; Güldenhaupt, Jörn ; Saum, Kai‐Uwe ; Janelidze, Shorena ; Holleczek, Bernd ; Rujescu, Dan ; Hansson, Oskar ; Gerwert, Klaus ; Brenner, Hermann

EMBO molecular medicine, 2018-05, Vol.10 (5), p.n/a [Periódico revisado por pares]

England: EMBO Press

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Título:
Amyloid blood biomarker detects Alzheimer's disease
Autor: Nabers, Andreas ; Perna, Laura ; Lange, Julia ; Mons, Ute ; Schartner, Jonas ; Güldenhaupt, Jörn ; Saum, Kai‐Uwe ; Janelidze, Shorena ; Holleczek, Bernd ; Rujescu, Dan ; Hansson, Oskar ; Gerwert, Klaus ; Brenner, Hermann
Assuntos: Aged ; Alzheimer Disease - blood ; Alzheimer Disease - diagnosis ; Alzheimer's disease ; Alzheimer's disease diagnosis ; Amyloid - blood ; Amyloid beta-Peptides - blood ; Amyloid beta-Peptides - chemistry ; Amyloid-β in blood plasma ; BioFINDER ; Biomarkers ; Biomarkers - blood ; Biomarkers - cerebrospinal fluid ; Biomedical Laboratory Science/Technology ; Biomedicinsk laboratorievetenskap/teknologi ; Blood ; Cerebrospinal fluid ; Cohort Studies ; Cross-Sectional Studies ; ESTHER ; Female ; Humans ; Immuno-infrared-sensor ; Male ; Medical and Health Sciences ; Medical Biotechnology ; Medicin och hälsovetenskap ; Medicinsk bioteknologi ; Middle Aged ; Neurodegenerative diseases ; Positron emission tomography ; Positron-Emission Tomography - methods ; Protein structure ; Protein Structure, Secondary ; ROC Curve ; Scanning ; Secondary structure ; Tomography
É parte de: EMBO molecular medicine, 2018-05, Vol.10 (5), p.n/a
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These authors contributed equally to this work
Correction added online on 5 May 2018 after first online publication: the affiliation of the corresponding author has been corrected.
Descrição: Alzheimer's disease (AD) is currently incurable, but there is general agreement that a minimally invasive blood biomarker for screening in preclinical stages would be crucial for future therapy. Diagnostic tools for detection of AD are either invasive like cerebrospinal fluid (CSF) biomarkers or expensive such as positron emission tomography (PET) scanning. Here, we determine the secondary structure change of amyloid‐β (Aβ) in human blood. This change used as blood amyloid biomarker indicates prodromal AD and correlates with CSF AD biomarkers and amyloid PET imaging in the cross‐sectional BioFINDER cohort. In a further population‐based longitudinal cohort (ESTHER), the blood biomarker detected AD several years before clinical diagnosis in baseline samples with a positive likelihood ratio of 7.9; that is, those who were diagnosed with AD over the years were 7.9 times more likely to test positive. This assay may open avenues for blood screening of early AD stages as a funnel for further more invasive and expensive tests. Synopsis Determination of the amyloid‐β secondary structure distribution in blood plasma by an immuno‐IR‐sensor correlates with PET scanning and CSF markers in Alzheimer's disease (AD) patients, with potentials to be an accurate, simple, and minimally invasive biomarker for early AD detection. The amyloid‐β (Aβ) secondary structure distribution in blood plasma can be directly determined by the secondary structure sensitive amide I band. Prodromal AD cases (BioFINDER study) showed significant correlations between the amide I frequency shift and PET scanning results or CSF biomarker values. Early AD identification (Esther) yielded in 71% sensitivity, 91% specificity, and a LR+ of 7.9–8 years before clinical symptoms appeared, in agreement with the BioFINDER study. The plasma biomarker may be used as a routine minimal‐invasive, low‐cost funnel to pre‐select individuals which should undergo lumbar puncture or PET scanning. Determination of the amyloid‐β secondary structure distribution in blood plasma by an immuno‐IR‐sensor correlates with PET scanning and CSF markers in Alzheimer's disease (AD) patients, with potentials to be an accurate, simple, and minimally invasive biomarker for early AD detection.
Editor: England: EMBO Press
Idioma: Inglês

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Amyloid blood biomarker detects Alzheimer's disease

Nabers, Andreas ; Perna, Laura ; Lange, Julia ; Mons, Ute ; Schartner, Jonas ; Güldenhaupt, Jörn ; Saum, Kai‐Uwe ; Janelidze, Shorena ; Holleczek, Bernd ; Rujescu, Dan ; Hansson, Oskar ; Gerwert, Klaus ; Brenner, Hermann

England: EMBO Press

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