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DNA methylation in newborns conceived by assisted reproductive technology

Håberg, Siri E ; Page, Christian M ; Lee, Yunsung ; Nustad, Haakon E ; Magnus, Maria C ; Haftorn, Kristine L ; Carlsen, Ellen Ø ; Denault, William R P ; Bohlin, Jon ; Jugessur, Astanand ; Magnus, Per ; Gjessing, Håkon K ; Lyle, Robert

Nature communications, 2022-04, Vol.13 (1), p.1896-1896, Article 1896 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
DNA methylation in newborns conceived by assisted reproductive technology
Autor: Håberg, Siri E ; Page, Christian M ; Lee, Yunsung ; Nustad, Haakon E ; Magnus, Maria C ; Haftorn, Kristine L ; Carlsen, Ellen Ø ; Denault, William R P ; Bohlin, Jon ; Jugessur, Astanand ; Magnus, Per ; Gjessing, Håkon K ; Lyle, Robert
Assuntos: Blood ; Cord blood ; Deoxyribonucleic acid ; DNA ; DNA Methylation ; Embryo transfer ; Embryos ; Epigenetics ; Fertility ; Fertilization ; Fertilization in Vitro ; Fetuses ; Genes ; Genomes ; Humans ; Infant, Newborn ; Infertility - genetics ; Neonates ; Neurodevelopment ; Reproductive Techniques, Assisted - adverse effects ; Reproductive technologies ; Reproductive technology
É parte de: Nature communications, 2022-04, Vol.13 (1), p.1896-1896, Article 1896
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
NFR/262700
Descrição: Assisted reproductive technology (ART) may affect fetal development through epigenetic mechanisms as the timing of ART procedures coincides with the extensive epigenetic remodeling occurring between fertilization and embryo implantation. However, it is unknown to what extent ART procedures alter the fetal epigenome. Underlying parental characteristics and subfertility may also play a role. Here we identify differences in cord blood DNA methylation, measured using the Illumina EPIC platform, between 962 ART conceived and 983 naturally conceived singleton newborns. We show that ART conceived newborns display widespread differences in DNA methylation, and overall less methylation across the genome. There were 607 genome-wide differentially methylated CpGs. We find differences in 176 known genes, including genes related to growth, neurodevelopment, and other health outcomes that have been associated with ART. Both fresh and frozen embryo transfer show DNA methylation differences. Associations persist after controlling for parents' DNA methylation, and are not explained by parental subfertility.
Editor: England: Nature Publishing Group
Idioma: Inglês;Norueguês

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DNA methylation in newborns conceived by assisted reproductive technology

Håberg, Siri E ; Page, Christian M ; Lee, Yunsung ; Nustad, Haakon E ; Magnus, Maria C ; Haftorn, Kristine L ; Carlsen, Ellen Ø ; Denault, William R P ; Bohlin, Jon ; Jugessur, Astanand ; Magnus, Per ; Gjessing, Håkon K ; Lyle, Robert

England: Nature Publishing Group

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