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Deciphering the cells of origin of squamous cell carcinomas

Sánchez-Danés, Adriana ; Blanpain, Cédric

Nature reviews. Cancer, 2018-09, Vol.18 (9), p.549-561 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Deciphering the cells of origin of squamous cell carcinomas
Autor: Sánchez-Danés, Adriana ; Blanpain, Cédric
Assuntos: Cancer ; Cancer cells ; Cancer research ; Carcinoma ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Cell differentiation ; Cell Lineage ; Esophageal Squamous Cell Carcinoma - genetics ; Esophageal Squamous Cell Carcinoma - metabolism ; Esophageal Squamous Cell Carcinoma - pathology ; Gene mutation ; Gene mutations ; Genes ; Genetic aspects ; Head and neck cancer ; Humans ; Lung Neoplasms - genetics ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Mutation ; Oncogenes - genetics ; Oncology, Experimental ; Phenotypes ; Skin ; Skin Neoplasms - genetics ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck - genetics ; Squamous Cell Carcinoma of Head and Neck - metabolism ; Squamous Cell Carcinoma of Head and Neck - pathology ; Stem Cells ; Tumor suppressor genes ; Tumors
É parte de: Nature reviews. Cancer, 2018-09, Vol.18 (9), p.549-561
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: Squamous cell carcinomas (SCCs) are among the most prevalent human cancers. SCC comprises a wide range of tumours originated from diverse anatomical locations that share common genetic mutations and expression of squamous differentiation markers. SCCs arise from squamous and non-squamous epithelial tissues. Here, we discuss the different studies in which the cell of origin of SCCs has been uncovered by expressing oncogenes and/or deleting tumour suppressor genes in the different cell lineages that compose these epithelia. We present evidence showing that the squamous differentiation phenotype of the tumour depends on the type of mutated oncogene and the cell of origin, which dictate the competence of the cells to initiate SCC formation, as well as on the aggressiveness and invasive properties of these tumours.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Deciphering the cells of origin of squamous cell carcinomas

Sánchez-Danés, Adriana ; Blanpain, Cédric

England: Nature Publishing Group

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