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Synthesis, characterization and photoinduced CO-release by manganese() complexes

Amorim, André L ; Guerreiro, Ana ; Glitz, Vinícius A ; Coimbra, Daniel F ; Bortoluzzi, Adailton J ; Caramori, Giovanni F ; Braga, Antonio L ; Neves, Ademir ; Bernardes, Gonçalo J. L ; Peralta, Rosely A

New journal of chemistry, 2020-07, Vol.44 (26), p.1892-191 [Periódico revisado por pares]

Cambridge: Royal Society of Chemistry

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  • Título:
    Synthesis, characterization and photoinduced CO-release by manganese() complexes
  • Autor: Amorim, André L ; Guerreiro, Ana ; Glitz, Vinícius A ; Coimbra, Daniel F ; Bortoluzzi, Adailton J ; Caramori, Giovanni F ; Braga, Antonio L ; Neves, Ademir ; Bernardes, Gonçalo J. L ; Peralta, Rosely A
  • Assuntos: Carbon monoxide ; Chemical compounds ; Crystallography ; Density functional theory ; Manganese ; Pharmacology
  • É parte de: New journal of chemistry, 2020-07, Vol.44 (26), p.1892-191
  • Notas: 1824854-1824856
    10.1039/d0nj02260h
    For ESI and crystallographic data in CIF or other electronic format see DOI
    Electronic supplementary information ()ESI available: Additional information concerning graphics and some data can be obtained free of charge. CCDC
  • Descrição: Herein, we report the CO-releasing activity of three new photoCORMs, two with nonbonding pyridine moieties and one with a benzyl group. Compounds [MnBr(CO) 3 (bpa-κ 2 )] ( 2 , where bpa = N -benzyl(2-pyridylmethyl)amine); [MnBr(CO) 3 (pmpea-κ 2 )] ( 3 , where pmpea = N -(2-pyridylmethyl)- N ′-(2-pyridylethyl)amine) and [MnBr(CO) 3 (bpea-κ 2 )] ( 4 , where bpea = N -bis(2-pyridylethyl)amine) were synthesized and characterized by common spectroscopic techniques (UV-Vis and IR). Density functional theory studies were also performed to provide new insights into the M-C bond and to assume the orbitals involved in the absorption transitions. Their CO-releasing activities were measured both in organic and in physiological media and compared to that of a previously published compound [Mn(CO) 3 (dpa-κ 3 )]Br ( 1 , where dpa = N -bis(2-pyridylmethyl)amine). An increase in the number of members of the chelate from five to six influenced the release of CO, affecting both the binding mode of the ligand and the CO-release process and affecting their potential use as CO-release carriers and therapeutic agents. Three new photoCORM, two with non two with nonbonding pyridine and one with benzyl group, were synthesised, and their CO-releasing properties evaluated for with regards to their elusive binding mode.
  • Editor: Cambridge: Royal Society of Chemistry
  • Idioma: Inglês
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