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Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure

Alcaino, Hernan ; Greig, Douglas ; Chiong, Mario ; Verdejo, Hugo ; Miranda, Rodrigo ; Concepcion, Roberto ; Vukasovic, José Luis ; Diaz-Araya, Guillermo ; Mellado, Rosemarie ; Garcia, Lorena ; Salas, Daniela ; Gonzalez, Leticia ; Godoy, Ivan ; Castro, Pablo ; Lavandero, Sergio

European journal of heart failure, 2008-07, Vol.10 (7), p.646-651 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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Título:
Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure
Autor: Alcaino, Hernan ; Greig, Douglas ; Chiong, Mario ; Verdejo, Hugo ; Miranda, Rodrigo ; Concepcion, Roberto ; Vukasovic, José Luis ; Diaz-Araya, Guillermo ; Mellado, Rosemarie ; Garcia, Lorena ; Salas, Daniela ; Gonzalez, Leticia ; Godoy, Ivan ; Castro, Pablo ; Lavandero, Sergio
Assuntos: Case-Control Studies ; Chronic Disease ; Chronic heart failure ; Endothelial function ; Extracellular superoxide dismutase ; Female ; Heart Failure - blood ; Heart Failure - enzymology ; Humans ; Male ; Middle Aged ; Oxidative Stress ; Statistics, Nonparametric ; Superoxide Dismutase - metabolism ; Uric acid ; Uric Acid - blood
É parte de: European journal of heart failure, 2008-07, Vol.10 (7), p.646-651
Notas: ArticleID:EJHF2008-05-008
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ark:/67375/WNG-RKQ47L0S-0
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Increased serum uric acid has been identified as an independent risk factor for cardiovascular disease. However, because of its antioxidant capacity, uric acid may play a beneficial role in endothelial function. This paradoxical relationship between uric acid and endothelial function in chronic heart failure patients remains poorly understood. Thirty-eight chronic heart failure patients (New York Heart Association functional class II-III, mean age 58±10 years and mean left ventricular ejection fraction 25±8%) and twelve age-and-sex-matched healthy controls were studied. Chronic heart failure patients showed higher uric acid levels (7.3±2.3 mg/dL vs. 6.1±0.2 mg/dL, p<0.05) and lower extracellular superoxide dismutase activity (136±36 U ml−1 min−1 vs. 203±61 U ml−1 min−1, p<0.01) and endothelium-dependent vasodilatation (4.0±1.6% v. 9.1±3.0%, p<0.01) when compared with control subjects. In chronic heart failure patients, correlations between both uric acid levels and extracellular superoxide dismutase activity (r=0.45; p<0.01), and uric acid and endothelium-dependent vasodilatation (r=0.35; p=0.03) were detected. These correlations were not observed in healthy individuals, suggesting a positive effect of uric acid on endothelial function partially mediated by modulation of extracellular superoxide dismutase activity in chronic heart failure.
Editor: England: Blackwell Publishing Ltd
Idioma: Inglês

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Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure

Alcaino, Hernan ; Greig, Douglas ; Chiong, Mario ; Verdejo, Hugo ; Miranda, Rodrigo ; Concepcion, Roberto ; Vukasovic, José Luis ; Diaz-Araya, Guillermo ; Mellado, Rosemarie ; Garcia, Lorena ; Salas, Daniela ; Gonzalez, Leticia ; Godoy, Ivan ; Castro, Pablo ; Lavandero, Sergio

England: Blackwell Publishing Ltd

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