Idioma:

Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma

Nagel, Stefan ; Ehrentraut, Stefan ; Meyer, Corinna ; Kaufmann, Maren ; Drexler, Hans G. ; MacLeod, Roderick A. F.

Leukemia & lymphoma, 2014-08, Vol.55 (8), p.1893-1903 [Periódico revisado por pares]

United States: Informa Healthcare

Texto completo disponível

Citações Citado por

Enviar para

Título:
Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma
Autor: Nagel, Stefan ; Ehrentraut, Stefan ; Meyer, Corinna ; Kaufmann, Maren ; Drexler, Hans G. ; MacLeod, Roderick A. F.
Assuntos: Acetylation ; Cell Line, Tumor ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - metabolism ; Cyclin D1 ; Forkhead Transcription Factors - metabolism ; Gene Expression ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; hematopoiesis ; Histones - metabolism ; homeobox ; Homeodomain Proteins - metabolism ; Humans ; Leukemia, B-Cell - genetics ; Leukemia, B-Cell - metabolism ; Lymphoma, B-Cell - genetics ; Lymphoma, B-Cell - metabolism ; Lymphoma, Mantle-Cell - genetics ; Lymphoma, Mantle-Cell - metabolism ; MSX1 Transcription Factor - antagonists & inhibitors ; MSX1 Transcription Factor - genetics ; MSX1 Transcription Factor - metabolism ; Protein Binding ; Signal Transduction ; Transcription Factors - metabolism ; Transcriptional Activation
É parte de: Leukemia & lymphoma, 2014-08, Vol.55 (8), p.1893-1903
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Abstract NKL homeobox gene MSX1 is physiologically expressed during embryonic hematopoiesis. Here, we detected MSX1 overexpression in three examples of mantle cell lymphoma (MCL) and one of acute myeloid leukemia (AML) by screening 96 leukemia/lymphoma cell lines via microarray profiling. Moreover, in silico analysis identified significant overexpression of MSX1 in 3% each of patients with MCL and AML, confirming aberrant activity in subsets of both types of malignancies. Comparative expression profiling analysis and subsequent functional studies demonstrated overexpression of histone acetyltransferase PHF16 together with transcription factors FOXC1 and HLXB9 as activators of MSX1 transcription. Additionally, we identified regulation of cyclin D1/CCND1 by MSX1 and its repressive cofactor histone H1C. Fluorescence in situ hybridization in MCL cells showed that t(11;14)(q13;q32) results in detachment of CCND1 from its corresponding repressive MSX1 binding site. Taken together, we uncovered regulators and targets of homeobox gene MSX1 in leukemia/lymphoma cells, supporting the view of a recurrent genetic network that is reactivated in malignant transformation.
Editor: United States: Informa Healthcare
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 6 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma

Nagel, Stefan ; Ehrentraut, Stefan ; Meyer, Corinna ; Kaufmann, Maren ; Drexler, Hans G. ; MacLeod, Roderick A. F.

United States: Informa Healthcare

Buscando em bases de dados remotas. Favor aguardar.