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Impact of the Human Cell Atlas on medicine

Rood, Jennifer E ; Maartens, Aidan ; Hupalowska, Anna ; Teichmann, Sarah A ; Regev, Aviv

Nature medicine, 2022-12, Vol.28 (12), p.2486-2496 [Periódico revisado por pares]

United States: Nature Publishing Group

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Título:
Impact of the Human Cell Atlas on medicine
Autor: Rood, Jennifer E ; Maartens, Aidan ; Hupalowska, Anna ; Teichmann, Sarah A ; Regev, Aviv
Assuntos: Cancer ; Coronaviruses ; COVID-19 ; CRISPR ; DNA methylation ; Drug Delivery Systems ; Genes ; Genomes ; Genomics ; Humans ; Infectious diseases ; Medicine ; Microscopy ; Neoplasms - genetics ; Neoplasms - therapy ; Proteins ; Rare diseases ; Regenerative Medicine ; Severe acute respiratory syndrome coronavirus 2 ; Spectrum analysis ; Therapeutic targets ; Tissue engineering ; Tomography ; Toxicity
É parte de: Nature medicine, 2022-12, Vol.28 (12), p.2486-2496
Descrição: Single-cell atlases promise to provide a 'missing link' between genes, diseases and therapies. By identifying the specific cell types, states, programs and contexts where disease-implicated genes act, we will understand the mechanisms of disease at the cellular and tissue levels and can use this understanding to develop powerful disease diagnostics; identify promising new drug targets; predict their efficacy, toxicity and resistance mechanisms; and empower new kinds of therapies, from cancer therapies to regenerative medicine. Here, we lay out a vision for the potential of cell atlases to impact the future of medicine, and describe how advances over the past decade have begun to realize this potential in common complex diseases, infectious diseases (including COVID-19), rare diseases and cancer.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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Impact of the Human Cell Atlas on medicine

Rood, Jennifer E ; Maartens, Aidan ; Hupalowska, Anna ; Teichmann, Sarah A ; Regev, Aviv

United States: Nature Publishing Group

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