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Mechanisms of carcinogenic potential of occupational exposure to manufactured nanomaterials

Alswady-Hoff, Mayes

2023

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  • Título:
    Mechanisms of carcinogenic potential of occupational exposure to manufactured nanomaterials
  • Autor: Alswady-Hoff, Mayes
  • Notas: Paper I: Effects on Human Bronchial Epithelial Cells Following Low-dose Chronic Exposure to Nanomaterials: A 6-Month Transformation Study. Santosh Phuyal, Mayes Kasem, Laura Rubio, Hanna L. Karlsson, Ricard Marcos, Vidar Skaug & Shanbeh Zienolddiny. Toxicology in Vitro 2017; doi: 10.1016/j.tiv.2017.07.016. The article is included in the thesis. Also available at: https://doi.org/10.1016/j.tiv.2017.07.016
  • Descrição: Advances in nanotechnology have made it possible to manufacture a wide range of nanomaterials with considerable improved properties and applications. The small particles are found in everything from cosmetic products like toothpaste and shampoo to electronics, textiles, paint, and packaging. However, due to the increased manufacturing and use of nanomaterials in industrial production, concerns have been raised about potential adverse health effects among exposed workers. Occupational exposure to nanomaterials may occur during design, manufacturing, utilization, and waste handling, with inhalation as the main exposure route. The aim of this thesis was to investigate cellular transformation ability and mechanisms of long-term exposure to titanium dioxide (TiO2) and multiwalled carbon nanotubes (MWCNT) using low and occupationally relevant doses. The results showed that both TiO2 and MWCNT had the ability to transform human bronchial epithelial cells, indicating their carcinogenic potential. These nanomaterials also induced changes in lipidomic and proteomic profiles, cell cycle, cell survival, and cell death mechanisms. The thesis contributes to a better understanding of the biological impact at the molecular level following exposure to nanomaterials.
  • Data de criação/publicação: 2023
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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