Idioma:

Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands

Duckworth, Brigette C ; Lafouresse, Fanny ; Wimmer, Verena C ; Broomfield, Benjamin J ; Dalit, Lennard ; Alexandre, Yannick O ; Sheikh, Amania A ; Qin, Raymond Z ; Alvarado, Carolina ; Mielke, Lisa A ; Pellegrini, Marc ; Mueller, Scott N ; Boudier, Thomas ; Rogers, Kelly L ; Groom, Joanna R

Nature immunology, 2021-04, Vol.22 (4), p.434-448 [Periódico revisado por pares]

United States: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands
Autor: Duckworth, Brigette C ; Lafouresse, Fanny ; Wimmer, Verena C ; Broomfield, Benjamin J ; Dalit, Lennard ; Alexandre, Yannick O ; Sheikh, Amania A ; Qin, Raymond Z ; Alvarado, Carolina ; Mielke, Lisa A ; Pellegrini, Marc ; Mueller, Scott N ; Boudier, Thomas ; Rogers, Kelly L ; Groom, Joanna R
Assuntos: Animals ; Arenaviridae Infections - genetics ; Arenaviridae Infections - immunology ; Arenaviridae Infections - metabolism ; Arenaviridae Infections - virology ; CCR7 protein ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - metabolism ; CD8-Positive T-Lymphocytes - virology ; Cell Differentiation ; Cell fate ; Cell Lineage ; Cells, Cultured ; Chemokine CXCL10 - genetics ; Chemokine CXCL10 - metabolism ; Chemokine CXCL9 - genetics ; Chemokine CXCL9 - metabolism ; Chemokines ; Chemotaxis, Leukocyte ; CXCL10 protein ; CXCR3 protein ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Disease Models, Animal ; Effector cells ; Genetic aspects ; Health aspects ; Host-Pathogen Interactions ; Immunologic Memory ; Immunological memory ; Interferon ; Interferon Type I - metabolism ; Ligands ; Lymph nodes ; Lymph Nodes - immunology ; Lymph Nodes - metabolism ; Lymph Nodes - virology ; Lymphatic system ; Lymphocytes ; Lymphocytes T ; Lymphocytic choriomeningitis virus - immunology ; Lymphocytic choriomeningitis virus - pathogenicity ; Medical examination ; Memory cells ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phenotype ; Precursor Cells, T-Lymphoid - immunology ; Precursor Cells, T-Lymphoid - metabolism ; Precursor Cells, T-Lymphoid - virology ; Receptor, Interferon alpha-beta - genetics ; Receptor, Interferon alpha-beta - metabolism ; Receptors, CCR7 - metabolism ; Receptors, CXCR3 - genetics ; Receptors, CXCR3 - metabolism ; Signal Transduction ; Stem Cell Niche ; Stem cells ; Stromal Cells - immunology ; Stromal Cells - metabolism ; T cells
É parte de: Nature immunology, 2021-04, Vol.22 (4), p.434-448
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Undefined-1
ObjectType-Feature-3
content type line 23
Descrição: T cells dynamically interact with multiple, distinct cellular subsets to determine effector and memory differentiation. Here, we developed a platform to quantify cell location in three dimensions to determine the spatial requirements that direct T cell fate. After viral infection, we demonstrated that CD8 effector T cell differentiation is associated with positioning at the lymph node periphery. This was instructed by CXCR3 signaling since, in its absence, T cells are confined to the lymph node center and alternatively differentiate into stem-like memory cell precursors. By mapping the cellular sources of CXCR3 ligands, we demonstrated that CXCL9 and CXCL10 are expressed by spatially distinct dendritic and stromal cell subsets. Unlike effector cells, retention of stem-like memory precursors in the paracortex is associated with CCR7 expression. Finally, we demonstrated that T cell location can be tuned, through deficiency in CXCL10 or type I interferon signaling, to promote effector or stem-like memory fates.
Editor: United States: Nature Publishing Group
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands

Duckworth, Brigette C ; Lafouresse, Fanny ; Wimmer, Verena C ; Broomfield, Benjamin J ; Dalit, Lennard ; Alexandre, Yannick O ; Sheikh, Amania A ; Qin, Raymond Z ; Alvarado, Carolina ; Mielke, Lisa A ; Pellegrini, Marc ; Mueller, Scott N ; Boudier, Thomas ; Rogers, Kelly L ; Groom, Joanna R

United States: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.