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Natural history of small index lesions suspicious for prostate cancer on multiparametric MRI: recommendations for interval imaging follow-up

Rais-Bahrami, Soroush ; Türkbey, Barış ; Rastinehad, Ardeshir R ; Walton-Diaz, Annerleim ; Hoang, Anthony N ; Siddiqui, M Minhaj ; Stamatakis, Lambros ; Truong, Hong ; Nix, Jeffrey W ; Vourganti, Srinivas ; Grant, Kinzya B ; Merino, Maria J ; Choyke, Peter L ; Pinto, Peter A

Diagnostic and interventional radiology (Ankara, Turkey), 2014-07, Vol.20 (4), p.293-298 [Peer Reviewed Journal]

Turkey: Aves Yayincilik Ltd. STI

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Title:
Natural history of small index lesions suspicious for prostate cancer on multiparametric MRI: recommendations for interval imaging follow-up
Author: Rais-Bahrami, Soroush ; Türkbey, Barış ; Rastinehad, Ardeshir R ; Walton-Diaz, Annerleim ; Hoang, Anthony N ; Siddiqui, M Minhaj ; Stamatakis, Lambros ; Truong, Hong ; Nix, Jeffrey W ; Vourganti, Srinivas ; Grant, Kinzya B ; Merino, Maria J ; Choyke, Peter L ; Pinto, Peter A
Subjects: Abdominal Imaging ; Aged ; Cohort Studies ; Contrast Media ; Disease Progression ; Follow-Up Studies ; Humans ; Image Enhancement ; Image-Guided Biopsy ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Prostate - pathology ; Prostatic Neoplasms - pathology ; Retrospective Studies
Is Part Of: Diagnostic and interventional radiology (Ankara, Turkey), 2014-07, Vol.20 (4), p.293-298
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: We aimed to determine the natural history of small index lesions identified on multiparametric-magnetic resonance imaging (MP-MRI) of the prostate by evaluating lesion-specific pathology and growth on serial MP-MRI. We performed a retrospective review of 153 patients who underwent a minimum of two MP-MRI sessions, on an institutional review board-approved protocol. Index lesion is defined as the lesion(s) with the highest cancer suspicion score based on initial MP-MRI of a patient, irrespective of size. Two study cohorts were identified: (1) patients with no index lesion or index lesion(s) ≤7 mm and (2) a subset with no index lesion or index lesion(s) ≤5 mm. Pathological analysis of the index lesions was performed following magnetic resonance/ultrasound fusion-guided biopsy. Growth rate of the lesions was calculated based on MP-MRI follow-up. Patients with small index lesions measuring ≤7 mm (n=42) or a subset with lesions ≤5 mm (n=20) demonstrated either benign findings (86.2% and 87.5%, respectively) or low grade Gleason 6 prostate cancer (13.8% and 12.5%, respectively) on lesion-specific targeted biopsies. These lesions demonstrated no significant change in size (P = 0.93 and P = 0.36) over a mean imaging period of 2.31±1.56 years and 2.40±1.77 years for ≤7 mm and ≤5 mm index lesion thresholds, respectively. These findings held true on subset analyses of patients who had a minimum of two-year interval follow-up with MP-MRI. Small index lesions of the prostate are pathologically benign lesions or occasionally low-grade cancers. Slow growth rate of these small index lesions on serial MP-MRI suggests a surveillance interval of at least two years without significant change.
Publisher: Turkey: Aves Yayincilik Ltd. STI
Language: English

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Natural history of small index lesions suspicious for prostate cancer on multiparametric MRI: recommendations for interval imaging follow-up

Rais-Bahrami, Soroush ; Türkbey, Barış ; Rastinehad, Ardeshir R ; Walton-Diaz, Annerleim ; Hoang, Anthony N ; Siddiqui, M Minhaj ; Stamatakis, Lambros ; Truong, Hong ; Nix, Jeffrey W ; Vourganti, Srinivas ; Grant, Kinzya B ; Merino, Maria J ; Choyke, Peter L ; Pinto, Peter A

Turkey: Aves Yayincilik Ltd. STI

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