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Viral Co-infection and Leprosy Outcomes: A Cohort Study

Machado, Paulo R L ; Machado, Lídia M ; Shibuya, Mayume ; Rego, Jamile ; Johnson, Warren D ; Glesby, Marshall J Joyce, Patricia

PLoS neglected tropical diseases, 2015-08, Vol.9 (8), p.e0003865-e0003865 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Viral Co-infection and Leprosy Outcomes: A Cohort Study
Autor: Machado, Paulo R L ; Machado, Lídia M ; Shibuya, Mayume ; Rego, Jamile ; Johnson, Warren D ; Glesby, Marshall J
Joyce, Patricia
Assuntos: Adolescent ; Adult ; Aged ; Cohort Studies ; Coinfection - complications ; Coinfection - microbiology ; Coinfection - virology ; Comorbidity ; Confidence intervals ; Development and progression ; Disease ; Edema ; Female ; Hepacivirus - physiology ; Hepatitis ; Hepatitis B - virology ; Hepatitis B virus ; Hepatitis B virus - physiology ; Hepatitis C - virology ; Hepatitis C virus ; HIV ; HIV Infections - virology ; HIV-1 - physiology ; Hospitals ; HTLV-I Infections - virology ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Human T-lymphotropic virus 1 - physiology ; Humans ; Immune response ; Immunology ; Infections ; Inflammation ; Leprosy ; Leprosy - complications ; Leprosy - microbiology ; Leprosy - virology ; Lymphocytes ; Male ; Medical research ; Medicine, Experimental ; Middle Aged ; Mycobacterium leprae ; Mycobacterium leprae - physiology ; Observations ; Studies ; Viral infections ; Virus diseases ; Young Adult
É parte de: PLoS neglected tropical diseases, 2015-08, Vol.9 (8), p.e0003865-e0003865
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The authors have declared that no competing interests exist.
Conceived and designed the experiments: PRLM WDJ MJG. Performed the experiments: PRLM LMM MS JR. Analyzed the data: PRLM MJG. Contributed reagents/materials/analysis tools: LMM JR. Wrote the paper: PRLM WDJ MJG.
Descrição: The role of the host immunity in determining leprosy clinical forms and complications is well recognized, implying that changes in the immune status may interfere with several aspects of the disease. Therefore, we hypothesized that the presence of viral co-infections and associated immunological changes will have a clinical impact on leprosy outcomes. The aim of our study was to determine the clinical impact of human immunodeficiency virus (HIV), human T cell lymphotrophic virus type 1 (HTLV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infection on the development of reactions, neuritis, neuropathy and relapses. Cohort study in 245 leprosy subjects from Bahia, Brazil. Patients were followed from the time of diagnosis until at least the end of multidrug therapy. Viral co-infection was detected in 36 out of the 245 patients (14.7%). Specific co-infection rates were 10.6% for HBV, 2.9% for HIV, 2.5% for HTLV-1 and 0.8% for HCV. All four groups of co-infected patients had higher rates of neuritis and nerve function impairment compared to non co-infected leprosy subjects. The relapse rate was also higher in the co-infected group (8.3%) versus patients without co-infection (1.9%); relative risk 4.37, 95% confidence interval 1.02-18.74. Leprosy patients should be screened for HBV, HCV, HIV and HTLV-1 co-infections. Besides contributing to better health care, this measure will facilitate the early detection of severe complications through targeting of higher risk patients.
Editor: United States: Public Library of Science
Idioma: Inglês

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Viral Co-infection and Leprosy Outcomes: A Cohort Study

Machado, Paulo R L ; Machado, Lídia M ; Shibuya, Mayume ; Rego, Jamile ; Johnson, Warren D ; Glesby, Marshall J Joyce, Patricia

United States: Public Library of Science

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