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Age-dependent changes in adenosine A1 receptor distribution and density within the nucleus tractus solitarii of normotensive and hypertensive rats

Carrettiero, D. C. ; Fior-Chadi, D. R.

Journal of Neural Transmission, 2008-08, Vol.115 (8), p.1109-1118 [Periódico revisado por pares]

Vienna: Springer Vienna

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Título:
Age-dependent changes in adenosine A1 receptor distribution and density within the nucleus tractus solitarii of normotensive and hypertensive rats
Autor: Carrettiero, D. C. ; Fior-Chadi, D. R.
Assuntos: Aging - metabolism ; Animals ; Autoradiography ; Basic Neurosciences ; Blood Pressure - physiology ; Data Interpretation, Statistical ; Genetics and Immunology - Original Article ; Hypertension - genetics ; Hypertension - metabolism ; Linear Models ; Male ; Medicine ; Medicine & Public Health ; Neurology ; Neurosciences ; Psychiatry ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Receptor, Adenosine A1 - metabolism ; Solitary Nucleus - cytology ; Solitary Nucleus - growth & development ; Solitary Nucleus - metabolism
É parte de: Journal of Neural Transmission, 2008-08, Vol.115 (8), p.1109-1118
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: This study shows the distribution and density of adenosine A1 receptor (A 1 R) within the nucleus tractus solitarii (NTS) of Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) from birth to adulthood (1, 15, 30 and 90 days old). The NTS shows heterogeneous distribution of A 1 R in dorsomedial/dorsolateral, subpostremal and medial/intermediate subnuclei. A 1 R decrease from rostral to caudal within dorsomedial/dorsolateral subnucleus in 15-, 30- and 90-day-old WKY and SHR. A 1 R increase from rostral to caudal subpostremal subnucleus in 30- and 90-day-old WKY, and in 15-, 30- and 90-day-old SHR. Furthermore, A 1 Rs are increased in SHR as compared with WKY within dorsomedial/dorsolateral in 30- and 90-day-old and within subpostremal of 15-, 30- and 90-day-old rats. Finally, A 1 Rs increase from 1- to 30-day-old rats. Medial/intermediate did not show any changes in A 1 R from rostral to caudal levels, age or strain. In summary, our result highlights the importance of A1 adenosine system regarding the neural control of blood pressure and the development of hypertension.
Editor: Vienna: Springer Vienna
Idioma: Inglês

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Age-dependent changes in adenosine A1 receptor distribution and density within the nucleus tractus solitarii of normotensive and hypertensive rats

Carrettiero, D. C. ; Fior-Chadi, D. R.

Vienna: Springer Vienna

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