Idioma:

Optimizing outcomes in pancreas transplantation: Impact of organ preservation time

Rudolph, Ehren N. ; Dunn, Ty B. ; Sutherland, David E. R. ; Kandaswamy, Raja ; Finger, Erik B.

Clinical transplantation, 2017-09, Vol.31 (9), p.n/a [Periódico revisado por pares]

Denmark

Texto completo disponível

Citações Citado por

Enviar para

Título:
Optimizing outcomes in pancreas transplantation: Impact of organ preservation time
Autor: Rudolph, Ehren N. ; Dunn, Ty B. ; Sutherland, David E. R. ; Kandaswamy, Raja ; Finger, Erik B.
Assuntos: Adult ; Aged ; Aged, 80 and over ; Cold Ischemia - adverse effects ; Cold Ischemia - statistics & numerical data ; Female ; Graft Survival ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; organ preservation ; Organ Preservation - adverse effects ; Organ Preservation - methods ; Organ Preservation - statistics & numerical data ; Outcome Assessment (Health Care) ; pancreas transplant ; Pancreas Transplantation ; preservation time ; Proportional Hazards Models ; Retrospective Studies ; Time Factors
É parte de: Clinical transplantation, 2017-09, Vol.31 (9), p.n/a
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Recent changes to pancreas graft allocation policy have increased the number of organs available for regional and distant sharing, which results in a corresponding increase in preservation time. We sought to systematically assess the impact of cold ischemia time (CIT) on outcomes post‐transplant. A retrospective review of 1253 pancreas transplants performed at a single transplant center was performed to correlate CIT to transplant outcomes. The rate of technical failure (TF) increased with 20+ hours of CIT, with a 2.7‐fold to 6.2‐fold increased rate of TF for pancreas after kidney (PAK), simultaneous pancreas and kidney (SPK), and pancreas transplants overall. Long‐term graft survival was best with <12 hours of CIT; graft failure increased 1.2‐fold to 1.4‐fold with 12‐24 hours of CIT and 2.2‐fold with 24+ hours. CIT had less influence on the pancreas transplant alone category than either SPK or PAK and had markedly more influence on grafts from older (age >25 years) and overweight (body mass index >25) donors. In the final analysis, grafts with <12 hours of CIT performed the best overall, and strategies that reduce CIT (such as early allocation, pre‐recovery cross‐matching, and chartered flights for organs) should be considered whenever possible.
Editor: Denmark
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Optimizing outcomes in pancreas transplantation: Impact of organ preservation time

Rudolph, Ehren N. ; Dunn, Ty B. ; Sutherland, David E. R. ; Kandaswamy, Raja ; Finger, Erik B.

Denmark

Buscando em bases de dados remotas. Favor aguardar.