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In vivo evaluation of analgesic and anti-inflammatory activity of hydroalcoholic extracts from Handroanthus impetiginosus and their chemical composition by UPLC/MS analysis

Da Silva, Ìcaro E F ; Zoca, Daniela G ; Silva, Gabriela N Andrade E ; Katchborian-Neto, Albert ; Cavallari, Pedro S Dos S R ; de Almeida, Samarah G ; Januário, Ana H ; Pauletti, Patricia M ; Andrade, João Victor ; Morais-Urano, Raquel P ; Cunha, Wilson Roberto ; Santos, Mario F C ; Silva, Márcio L A E

Natural product research, 2023-08, Vol.37 (16), p.2801-2807 [Periódico revisado por pares]

England: Taylor & Francis Ltd

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Título:
In vivo evaluation of analgesic and anti-inflammatory activity of hydroalcoholic extracts from Handroanthus impetiginosus and their chemical composition by UPLC/MS analysis
Autor: Da Silva, Ìcaro E F ; Zoca, Daniela G ; Silva, Gabriela N Andrade E ; Katchborian-Neto, Albert ; Cavallari, Pedro S Dos S R ; de Almeida, Samarah G ; Januário, Ana H ; Pauletti, Patricia M ; Andrade, João Victor ; Morais-Urano, Raquel P ; Cunha, Wilson Roberto ; Santos, Mario F C ; Silva, Márcio L A E
Assuntos: Analgesics ; Anti-inflammatory agents ; Bark ; Carrageenan ; Chemical composition ; Edema ; Flavonoids ; Flowers ; Handroanthus impetiginosus ; Herbal medicine ; In vivo methods and tests ; Inflammation ; Leaves ; Medicinal plants ; Metabolites ; Oral administration ; Plant extracts
É parte de: Natural product research, 2023-08, Vol.37 (16), p.2801-2807
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: This study demonstrates analgesic and anti-inflammatory properties of hydroalcoholic extracts of leaves, bark and flowers from the (Bignoniaceae) plant, recognized as 'Ipê roxo' in Brazil. The extracts were evaluated in male Swiss albino mice via oral administration. Moreover, results of the paw oedema test induced by carrageenan revealed that extracts of leaves and bark displayed relevant anti-inflammatory activity potential at the dosage of 100 mg/kg, 300 mg/kg, and 500 mg/kg. Likewise, the results obtained for leaves and flowers extracts suggested potent analgesic action in the conventional hot plate test. UPLC/MS analysis of the hydroalcoholic extracts samples identified metabolites belonging to several classes, mainly naphthoquinones and iridoids derivatives as well as flavonoids. Thus, the obtained results indicate that the extracts of plant parts could be considered as a complementary herbal medicine for the treatment of pain and inflammation disorders.
Editor: England: Taylor & Francis Ltd
Idioma: Inglês

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In vivo evaluation of analgesic and anti-inflammatory activity of hydroalcoholic extracts from Handroanthus impetiginosus and their chemical composition by UPLC/MS analysis

England: Taylor & Francis Ltd

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