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The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment

Ni, Yanghong ; Zhou, Xiaoting ; Yang, Jia ; Shi, Houhui ; Li, Hongyi ; Zhao, Xia ; Ma, Xuelei

Frontiers in cell and developmental biology, 2021-05, Vol.9, p.637675-637675 [Periódico revisado por pares]

Frontiers Media S.A

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  • Título:
    The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment
  • Autor: Ni, Yanghong ; Zhou, Xiaoting ; Yang, Jia ; Shi, Houhui ; Li, Hongyi ; Zhao, Xia ; Ma, Xuelei
  • Assuntos: antineoplastic drug resistance ; CAFs ; Cell and Developmental Biology ; cell-cell interplays ; MSCs ; TAMs ; tumor microenvironment
  • É parte de: Frontiers in cell and developmental biology, 2021-05, Vol.9, p.637675-637675
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    Reviewed by: Hongzhi Du, Hubei University of Chinese Medicine, China; Yinlong Zhang, National Center for Nanoscience and Technology (CAS), China
    These authors have contributed equally to this work and share first authorship
    This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Cell and Developmental Biology
    Edited by: Yong Song, Nanjing University, China
  • Descrição: Cancer cells resistance to various therapies remains to be a key challenge nowadays. For a long time, scientists focused on tumor cells themselves for the mechanisms of acquired drug resistance. However, recent evidence showed that tumor microenvironment (TME) is essential for regulating immune escape, drug resistance, progression and metastasis of malignant cells. Reciprocal interactions between cancer cells and non-malignant cells within this milieu often reshape the TME and promote drug resistance. Therefore, advanced knowledge about these sophisticated interactions is significant for the design of effective therapeutic approaches. In this review, we highlight cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), myeloid-derived suppressor cells (MDSCs), T-regulatory lymphocytes (Tregs), mesenchymal stem cells (MSCs), cancer-associated adipocytes (CAAs), and tumor endothelial cells (TECs) existing in TME, as well as their multiple cross-talk with tumor cells, which eventually endows tumor cells with therapeutic resistance.
  • Editor: Frontiers Media S.A
  • Idioma: Inglês
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