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Structural elucidation of the O-antigen of the Shigella flexneri provisional serotype 88-893: structural and serological similarities with S. flexneri provisional serotype Y394 (1c)

Foster, R.A. ; Carlin, N.I.A. ; Majcher, M. ; Tabor, H. ; Ng, L.-K. ; Widmalm, G.

Carbohydrate research, 2011-05, Vol.346 (6), p.872-876 [Periódico revisado por pares]

Netherlands: Elsevier Ltd

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Título:
Structural elucidation of the O-antigen of the Shigella flexneri provisional serotype 88-893: structural and serological similarities with S. flexneri provisional serotype Y394 (1c)
Autor: Foster, R.A. ; Carlin, N.I.A. ; Majcher, M. ; Tabor, H. ; Ng, L.-K. ; Widmalm, G.
Assuntos: antigens ; Carbohydrate Sequence ; carbon ; Lipopolysaccharide ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Molecular Sequence Data ; NMR ; nuclear magnetic resonance spectroscopy ; O Antigens - chemistry ; O-Acetylation ; polysaccharides ; serological surveys ; serotypes ; Serotyping ; Shigella flexneri ; Shigella flexneri - chemistry ; stable isotopes
É parte de: Carbohydrate research, 2011-05, Vol.346 (6), p.872-876
Notas: http://dx.doi.org/10.1016/j.carres.2011.02.013
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Descrição: The structure of the repeating unit of the O-antigen polysaccharide from Shigella flexneri provisional serotype 88-893 has been determined. 1H and 13C NMR spectroscopy as well as 2D NMR experiments were employed to elucidate the structure. The carbohydrate part of the hexasaccharide repeating unit is identical to the previously elucidated structure of the O-polysaccharide from S. flexneri prov. serotype Y394. The O-antigen of S. flexneri prov. serotype 88-893 carries 0.7mol O-acetyl group per repeating unit located at O-2 of the 3-substituted rhamnosyl residue, as identified by H2BC and BS-CT-HMBC NMR experiments. The O-antigen polysaccharide is composed of hexasaccharide repeating units with the following structure: →2)-α-l-Rhap-(1→2)-α-l-Rhap-(1→3)-α-l-Rhap2Ac-(1→3)[α-d-Glcp-(1→2)-α-d-Glcp-(1→4)]-β-d-GlcpNAc-(1→. Serological studies showed that type antigens for the two provisional serotypes are identical; in addition 88-893 expresses S. flexneri group factor 6 antigen. We propose that provisional serotypes Y394 and 88-893 be designated as two new serotypes 7a and 7b, respectively, in the S. flexneri typing scheme.
Editor: Netherlands: Elsevier Ltd
Idioma: Inglês

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Structural elucidation of the O-antigen of the Shigella flexneri provisional serotype 88-893: structural and serological similarities with S. flexneri provisional serotype Y394 (1c)

Foster, R.A. ; Carlin, N.I.A. ; Majcher, M. ; Tabor, H. ; Ng, L.-K. ; Widmalm, G.

Netherlands: Elsevier Ltd

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