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Serum copeptin and cortisol do not accurately predict sickle cell anaemia vaso-occlusive crisis as C-reactive protein

Akinlade, Kehinde Sola ; Atere, Adedeji David ; Olaniyi, John Ayodele ; Rahamon, Sheu Kadiri ; Adewale, Christiana Odunayo Chang, Alice Y. W.

PloS one, 2013-11, Vol.8 (11), p.e77913 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Serum copeptin and cortisol do not accurately predict sickle cell anaemia vaso-occlusive crisis as C-reactive protein
Autor: Akinlade, Kehinde Sola ; Atere, Adedeji David ; Olaniyi, John Ayodele ; Rahamon, Sheu Kadiri ; Adewale, Christiana Odunayo
Chang, Alice Y. W.
Assuntos: Adolescent ; Adult ; Analysis ; Anemia ; Anemia, Sickle Cell - blood ; Anemia, Sickle Cell - pathology ; Area Under Curve ; Arthritis ; Biomarkers - blood ; C-reactive protein ; C-Reactive Protein - metabolism ; Case-Control Studies ; Cell adhesion & migration ; Control methods ; Corticosteroids ; Cortisol ; Crises ; Data processing ; Diagnostic systems ; Enzyme-linked immunosorbent assay ; Genotypes ; Glucocorticoids ; Glycopeptides - blood ; Hematology ; Hormones ; Hospitals ; Humans ; Hydrocortisone - blood ; Illnesses ; Inflammation ; Medical diagnosis ; Medical prognosis ; Pain ; Pathology ; Plasma ; Pollution control ; Prognosis ; Prospective Studies ; Proteins ; ROC Curve ; Serum levels ; Sickle cell anemia ; Sickle cell disease ; Steady state ; Steroids ; Steroids (Organic compounds) ; Stress ; Tropical diseases ; VOCs ; Volatile organic compounds ; Young Adult
É parte de: PloS one, 2013-11, Vol.8 (11), p.e77913
Notas: Conceived and designed the experiments: KSA JAO SKR. Performed the experiments: ADA COA. Analyzed the data: SKR KSA. Contributed reagents/materials/analysis tools: KSA ADA COA. Wrote the paper: SKR KSA.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: This study assessed the diagnostic performance and prognostic properties of C-reactive protein (CRP), copeptin and cortisol in individuals with sickle cell anaemia (SCA). Prospective case-control study. Sixty consecutive SCA subjects (18-40 years) comprising 30 subjects in the steady state and 30 subjects in vaso-occlusive crisis (VOC) were recruited into this study. Thirty (30) apparently healthy individuals with HbAA genotype served as controls. ELISA was used for the determination of serum levels of copeptin, CRP and cortisol. Data obtained were statistically analyzed using the Student's t-test and Mann Whitney U as appropriate and P<0.05 was considered significant. SCA subjects in VOC had significantly lower copeptin level and significantly higher CRP level compared with controls. However, serum levels of copeptin, cortisol and CRP were significantly higher in SCA subjects in VOC compared with SCA subjects in steady state. Furthermore, CRP had the widest Area under the ROC curve (AUROC) than copeptin and cortisol. No significant difference was observed in the levels of copeptin, CRP and cortisol when SCA subjects in VOC who were hospitalized for less ≤ 5 days were compared with subjects who had longer stays. It could be concluded that C-reactive protein has a superior diagnostic performance for vaso-occlusive crisis in individuals with sickle cell anaemia and that C-reactive protein, cortisol and copeptin are not good prognostic markers in SCA subjects in vaso-occlusive crisis.
Editor: United States: Public Library of Science
Idioma: Inglês

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Serum copeptin and cortisol do not accurately predict sickle cell anaemia vaso-occlusive crisis as C-reactive protein

Akinlade, Kehinde Sola ; Atere, Adedeji David ; Olaniyi, John Ayodele ; Rahamon, Sheu Kadiri ; Adewale, Christiana Odunayo Chang, Alice Y. W.

United States: Public Library of Science

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