Idioma:

Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice

Abdel-Fattah, Abdel-Fattah Mohamed ; Matsumoto, Kinzo ; Watanabe, Hiroshi

European journal of pharmacology, 2000-07, Vol.400 (1), p.89-97 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

Texto completo disponível

Citações Citado por

Enviar para

Título:
Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice
Autor: Abdel-Fattah, Abdel-Fattah Mohamed ; Matsumoto, Kinzo ; Watanabe, Hiroshi
Assuntos: Analgesics, Non-Narcotic - pharmacology ; Animals ; Antinociception ; Benzoquinones - pharmacology ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Drug Tolerance ; Formalin test ; General pharmacology ; Injections, Intraventricular ; Male ; Medical sciences ; Mice ; Motor Activity - drug effects ; Naloxone - pharmacology ; Naltrexone - analogs & derivatives ; Naltrexone - pharmacology ; Nigella sativa oil ; Opioid system ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Oils - pharmacology ; Plants, Medicinal ; Thymoquinone
É parte de: European journal of pharmacology, 2000-07, Vol.400 (1), p.89-97
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, were examined in mice. The p.o. administration of N. sativa oil (50–400 mg/kg) dose-dependently suppressed the nociceptive response in the hot-plate test, tail-pinch test, acetic acid-induced writhing test and in the early phase of the formalin test. The systemic administration (2.5–10 mg/kg, p.o. and 1–6 mg/kg, i.p.) and the i.c.v. injection (1–4 μg/mouse) of thymoquinone attenuated the nociceptive response in not only the early phase but also the late phase of the formalin test. Naloxone injected s.c. (1 mg/kg) significantly blocked N. sativa oil- and thymoquinone-induced antinociception in the early phase of the formalin test. Moreover, the i.c.v. injection of naloxone (10 μg/mouse), the μ 1-opioid receptor antagonist, naloxonazine (1–5 μg/mouse), or the κ-opioid receptor antagonist, nor-binaltorphimine (1–5 μg/mouse), significantly reversed thymoquinone-induced antinociception in the early phase but not the late phase of the formalin test, whereas the δ-opioid receptor antagonist, naltrindole (1–5 ng/mouse, i.c.v.), had no effect on either phase. The antinociceptive effect of morphine was significantly reduced in thymoquinone- and N. sativa oil-tolerant mice, but not vice versa. These results suggest that N. sativa oil and thymoquinone produce antinociceptive effects through indirect activation of the supraspinal μ 1- and κ-opioid receptor subtypes.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice

Abdel-Fattah, Abdel-Fattah Mohamed ; Matsumoto, Kinzo ; Watanabe, Hiroshi

Amsterdam: Elsevier B.V

Buscando em bases de dados remotas. Favor aguardar.