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Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil

Santos, Genario ; Figueira, Estela Regina Ramos ; D’Albuquerque, Luiz Augusto Carneiro ; Lisboa, Paulo Bittencourt ; de Almeida, Marcio Dias ; Filgueira, Norma Arteiro ; Boin, Ilka ; Porta, Gilda ; da Silva, Rita de Cássia Martins Alves ; Viana, Cyntia Ferreira Gomes ; Faria, Luciana Costa ; Alvares-da-Silva, Mario Reis ; de Moraes, Adriano Claudio Pereira ; Morsoletto, Daphne Benatti Goncalves ; Codes, Liana ; Paraná, Raymundo

Annals of hepatology, 2021-07, Vol.23, p.100310-100310, Article 100310 [Periódico revisado por pares]

Mexico: Elsevier España, S.L.U

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Título:
Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil
Autor: Santos, Genario ; Figueira, Estela Regina Ramos ; D’Albuquerque, Luiz Augusto Carneiro ; Lisboa, Paulo Bittencourt ; de Almeida, Marcio Dias ; Filgueira, Norma Arteiro ; Boin, Ilka ; Porta, Gilda ; da Silva, Rita de Cássia Martins Alves ; Viana, Cyntia Ferreira Gomes ; Faria, Luciana Costa ; Alvares-da-Silva, Mario Reis ; de Moraes, Adriano Claudio Pereira ; Morsoletto, Daphne Benatti Goncalves ; Codes, Liana ; Paraná, Raymundo
Assuntos: Acetaminophen - adverse effects ; Acute liver failure ; Adolescent ; Adult ; Brazil ; Chemical and Drug Induced Liver Injury - complications ; Chemical and Drug Induced Liver Injury - diagnosis ; Chemical and Drug Induced Liver Injury - epidemiology ; Child ; Dietary Supplements - adverse effects ; Drug induced liver injury ; Female ; Humans ; Liver Failure, Acute - diagnosis ; Liver Failure, Acute - etiology ; Liver Failure, Acute - surgery ; Liver injury ; Liver Transplantation ; Male ; Middle Aged ; Retrospective Studies ; Young Adult
É parte de: Annals of hepatology, 2021-07, Vol.23, p.100310-100310, Article 100310
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SourceType-Scholarly Journals-1
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Descrição: Little is known about the etiology of acute liver failure (ALF) in Latin America. The objective of this paper is to investigate the main etiologies of ALF in Brazil, including Drug Induced Liver Injury (DILI) using stringent causality criteria. All the cases of individuals who underwent liver transplantation (LT) in 12 centers in Brazil for ALF were reviewed. When DILI was stated as the cause of ALF, causality criteria were applied on site by the main investigator in order to rule out other etiologies. 325 individuals had ALF mainly for unknown reasons (34%), DILI (27%) and AIH (18%). Reassessment of the 89 cases of DILI, using stringent causality criteria, revealed that in only 42 subjects could DILI be confirmed as the cause of ALF. Acetaminophen (APAP) toxicity (n = 3) or DILI due to herbal and dietary supplements (HDS) (n = 2) were not commonly observed. Undetermined etiology and DILI are the main causes of ALF in Brazil. However, APAP toxicity and DILI due to HDS are mostly uncommon.
Editor: Mexico: Elsevier España, S.L.U
Idioma: Inglês

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Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil

Mexico: Elsevier España, S.L.U

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