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Emergence and potential for spread of Chikungunya virus in Brazil

Nunes, Marcio Roberto Teixeira ; Faria, Nuno Rodrigues ; de Vasconcelos, Janaina Mota ; Golding, Nick ; Kraemer, Moritz U G ; de Oliveira, Layanna Freitas ; Azevedo, Raimunda do Socorro da Silva ; da Silva, Daisy Elaine Andrade ; da Silva, Eliana Vieira Pinto ; da Silva, Sandro Patroca ; Carvalho, Valéria Lima ; Coelho, Giovanini Evelim ; Cruz, Ana Cecília Ribeiro ; Rodrigues, Sueli Guerreiro ; Vianez, Jr, Joao Lídio da Silva Gonçalves ; Nunes, Bruno Tardelli Diniz ; Cardoso, Jedson Ferreira ; Tesh, Robert B ; Hay, Simon I ; Pybus, Oliver G ; Vasconcelos, Pedro Fernando da Costa

BMC medicine, 2015-04, Vol.13 (1), p.102-102, Article 102 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Emergence and potential for spread of Chikungunya virus in Brazil
Autor: Nunes, Marcio Roberto Teixeira ; Faria, Nuno Rodrigues ; de Vasconcelos, Janaina Mota ; Golding, Nick ; Kraemer, Moritz U G ; de Oliveira, Layanna Freitas ; Azevedo, Raimunda do Socorro da Silva ; da Silva, Daisy Elaine Andrade ; da Silva, Eliana Vieira Pinto ; da Silva, Sandro Patroca ; Carvalho, Valéria Lima ; Coelho, Giovanini Evelim ; Cruz, Ana Cecília Ribeiro ; Rodrigues, Sueli Guerreiro ; Vianez, Jr, Joao Lídio da Silva Gonçalves ; Nunes, Bruno Tardelli Diniz ; Cardoso, Jedson Ferreira ; Tesh, Robert B ; Hay, Simon I ; Pybus, Oliver G ; Vasconcelos, Pedro Fernando da Costa
Assuntos: Adolescent ; Adult ; Aged ; Analysis ; Brazil - epidemiology ; Chikungunya Fever - epidemiology ; Chikungunya Fever - transmission ; Chikungunya Fever - virology ; Chikungunya virus - genetics ; Child ; Child, Preschool ; Disease Outbreaks ; Epidemiology ; Female ; Genotype ; Health aspects ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Phylogeny ; Public Health ; Risk ; Young Adult
É parte de: BMC medicine, 2015-04, Vol.13 (1), p.102-102, Article 102
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: In December 2013, an outbreak of Chikungunya virus (CHIKV) caused by the Asian genotype was notified in the Caribbean. The outbreak has since spread to 38 regions in the Americas. By September 2014, the first autochthonous CHIKV infections were confirmed in Oiapoque, North Brazil, and in Feira de Santana, Northeast Brazil. We compiled epidemiological and clinical data on suspected CHIKV cases in Brazil and polymerase-chain-reaction-based diagnostic was conducted on 68 serum samples from patients with symptom onset between April and September 2014. Two imported and four autochthonous cases were selected for virus propagation, RNA isolation, full-length genome sequencing, and phylogenetic analysis. We then followed CDC/PAHO guidelines to estimate the risk of establishment of CHIKV in Brazilian municipalities. We detected 41 CHIKV importations and 27 autochthonous cases in Brazil. Epidemiological and phylogenetic analyses indicated local transmission of the Asian CHIKV genotype in Oiapoque. Unexpectedly, we also discovered that the ECSA genotype is circulating in Feira de Santana. The presumed index case of the ECSA genotype was an individual who had recently returned from Angola and developed symptoms in Feira de Santana. We estimate that, if CHIKV becomes established in Brazil, transmission could occur in 94% of municipalities in the country and provide maps of the risk of importation of each strain of CHIKV in Brazil. The etiological strains associated with the early-phase CHIKV outbreaks in Brazil belong to the Asian and ECSA genotypes. Continued surveillance and vector mitigation strategies are needed to reduce the future public health impact of CHIKV in the Americas.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Emergence and potential for spread of Chikungunya virus in Brazil

England: BioMed Central Ltd

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