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Evaluation of Pertussis in U.S. Marine Corps Trainees

Jansen, D. L. ; Gray, G. C. ; Putnam, S. D. ; Lynn, F. ; Meade, B. D.

Clinical infectious diseases, 1997-11, Vol.25 (5), p.1099-1107 [Periódico revisado por pares]

Chicago, IL: The University of Chicago Press

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Título:
Evaluation of Pertussis in U.S. Marine Corps Trainees
Autor: Jansen, D. L. ; Gray, G. C. ; Putnam, S. D. ; Lynn, F. ; Meade, B. D.
Assuntos: Adhesins, Bacterial - immunology ; Adolescent ; Adult ; Antibodies ; Antibodies, Bacterial - blood ; Antigens, Bacterial - immunology ; Bacterial diseases ; Bacterial Proteins - immunology ; Biological and medical sciences ; Bordetella pertussis ; Clinical Articles ; Cough ; Ent and stomatologic bacterial diseases ; Enzyme linked immunosorbent assay ; Fimbriae ; Fimbriae Proteins ; Geometric mean ; Hemagglutinins - immunology ; Human bacterial diseases ; Humans ; Infections ; Infectious diseases ; Male ; Marine Corps ; Medical sciences ; Military Personnel ; Pilot Projects ; Polymerase Chain Reaction ; Porins - genetics ; United States ; Virulence Factors, Bordetella ; Whooping cough ; Whooping Cough - diagnosis ; Whooping Cough - epidemiology ; Whooping Cough - microbiology
É parte de: Clinical infectious diseases, 1997-11, Vol.25 (5), p.1099-1107
Notas: ark:/67375/HXZ-0RN72V63-D
istex:51ABD8B08A45BA51D900FF81AD2803B796590152
Reprints or correspondence: D. L. Jansen, Mail Code HFM-490, Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, Maryland 20852.
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Descrição: One hundred twenty male U.S. Marine Corps trainees with histories of at least 7 days of cough underwent evaluation for Bordetella pertussis infection by culture, B. pertussis-specific polymerase chain reaction (PCR) analysis, and serology. Antibody levels in preexposure, acute-phase, and convalescent-phase serum samples were measured in a microagglutination assay and in enzyme linked immunosorbent assays (ELISAs) for IgG and IgA antibodies to pertussis toxin, filamentous hemagglutinin, pertactin, and fimbriae types 2 and 3. Culture and PCR analysis revealed that none of the patients were positive for B. pertussis; however, 20 of 120 trainees had serological evidence of B. pertussis infection. Of these cases, one was confirmed by a rise in the level of antibody to pertussis toxin, and six were classified as probable by increases in levels of antibodies measured by two or more assays. Of the 20 individuals with serological evidence of infection, 16 had rises in levels of antibodies to fimbriae or agglutinating antibodies. The utility of ELISA for detecting antibodies to fimbriae and the microagglutination assay for diagnosing pertussis in adults should be evaluated by application to larger and more diverse study populations. These results indicate that pertussis should be considered in the diagnosis of coughing illness in military populations.
Editor: Chicago, IL: The University of Chicago Press
Idioma: Inglês

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Evaluation of Pertussis in U.S. Marine Corps Trainees

Jansen, D. L. ; Gray, G. C. ; Putnam, S. D. ; Lynn, F. ; Meade, B. D.

Chicago, IL: The University of Chicago Press

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