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Estrogen Receptors: Therapeutic Perspectives for the Treatment of Cardiac Dysfunction after Myocardial Infarction

da Silva, Jaqueline S ; Montagnoli, Tadeu L ; Rocha, Bruna S ; Tacco, Matheus L C A ; Marinho, Sophia C P ; Zapata-Sudo, Gisele

International journal of molecular sciences, 2021-01, Vol.22 (2), p.525 [Periódico revisado por pares]

Switzerland: MDPI AG

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Estrogen Receptors: Therapeutic Perspectives for the Treatment of Cardiac Dysfunction after Myocardial Infarction
Autor: da Silva, Jaqueline S ; Montagnoli, Tadeu L ; Rocha, Bruna S ; Tacco, Matheus L C A ; Marinho, Sophia C P ; Zapata-Sudo, Gisele
Assuntos: 17β-Estradiol ; Animals ; Apoptosis ; cardiac dysfunction ; Cardiomyocytes ; Cardiovascular disease ; Cardiovascular diseases ; Cell proliferation ; Clinical aspects ; Endothelial cells ; Endothelial Cells - metabolism ; Endothelial Cells - pathology ; Estradiol - therapeutic use ; estrogen receptor ; Estrogen Receptor alpha - genetics ; Estrogen Receptor beta - genetics ; Estrogen receptors ; Estrogens ; Estrogens - genetics ; Estrogens - metabolism ; Female ; Genomics ; Health services ; Humans ; Hypertrophy ; Immune system ; Inflammation ; ischemia-reperfusion ; Kinases ; Mortality ; Myocardial infarction ; Myocardial Infarction - drug therapy ; Myocardial Infarction - genetics ; Myocardial Infarction - pathology ; Myocytes, Cardiac - metabolism ; Myocytes, Cardiac - pathology ; Necrosis ; Nitric oxide ; Receptors, Estrogen - genetics ; Receptors, G-Protein-Coupled - genetics ; Review ; Sex hormones
É parte de: International journal of molecular sciences, 2021-01, Vol.22 (2), p.525
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Estrogen receptors (ER) mediate functions beyond their endocrine roles, as modulation of cardiovascular, renal, and immune systems through anti-inflammatory and anti-apoptotic effects, preventing necrosis of cardiomyocytes and endothelial cells, and attenuating cardiac hypertrophy. Estradiol (E2) prevents cardiac dysfunction, increases nitric oxide synthesis, and reduces the proliferation of vascular cells, yielding protective effects, regardless of gender. Such actions are mediated by ER (ER-alpha (ERα), ER-beta (ERβ), or G protein-coupled ER (GPER)) through genomic or non-genomic pathways, which regulate cardiovascular function and prevent tissue remodeling. Despite the extensive knowledge on the cardioprotective effects of estrogen, clinical studies conducted on myocardial infarction (MI) and cardiovascular diseases still include favorable and unfavorable profiles. The purpose of this review is to provide up-to-date information regarding molecular, preclinical, and clinical aspects of cardiovascular E2 effects and ER modulation as a potential therapeutic target for the treatment of MI-induced cardiac dysfunction.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Estrogen Receptors: Therapeutic Perspectives for the Treatment of Cardiac Dysfunction after Myocardial Infarction

da Silva, Jaqueline S ; Montagnoli, Tadeu L ; Rocha, Bruna S ; Tacco, Matheus L C A ; Marinho, Sophia C P ; Zapata-Sudo, Gisele

Switzerland: MDPI AG

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