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Differential Expression of NADPH Oxidases Depends on Skeletal Muscle Fiber Type in Rats

Loureiro, Adriano César Carneiro ; Rêgo-Monteiro, Igor Coutinho do ; Louzada, Ruy A. ; Ortenzi, Victor Hugo ; Aguiar, Angélica Ponte de ; Abreu, Ewerton Sousa de ; Cavalcanti-de-Albuquerque, João Paulo Albuquerque ; Hecht, Fabio ; Oliveira, Ariclécio Cunha de ; Ceccatto, Vânia Marilande ; Fortunato, Rodrigo S. ; Carvalho, Denise P. Quiles, José L.

Oxidative medicine and cellular longevity, 2016-01, Vol.2016, p.6738701-10 [Periódico revisado por pares]

United States: Hindawi Publishing Corporation

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Título:
Differential Expression of NADPH Oxidases Depends on Skeletal Muscle Fiber Type in Rats
Autor: Loureiro, Adriano César Carneiro ; Rêgo-Monteiro, Igor Coutinho do ; Louzada, Ruy A. ; Ortenzi, Victor Hugo ; Aguiar, Angélica Ponte de ; Abreu, Ewerton Sousa de ; Cavalcanti-de-Albuquerque, João Paulo Albuquerque ; Hecht, Fabio ; Oliveira, Ariclécio Cunha de ; Ceccatto, Vânia Marilande ; Fortunato, Rodrigo S. ; Carvalho, Denise P.
Quiles, José L.
Assuntos: Adaptation ; Animals ; Antioxidants - metabolism ; Biosynthesis ; Enzymes ; Exercise ; Fitness training programs ; Glycolysis ; Laboratory animals ; Male ; Mitochondria ; Muscle Fibers, Skeletal - enzymology ; Musculoskeletal system ; NADPH Oxidases - genetics ; NADPH Oxidases - metabolism ; Oxidation-Reduction ; Oxygen Consumption ; Physical Conditioning, Animal ; Physical fitness ; Physiology ; Rats, Wistar ; Real-Time Polymerase Chain Reaction ; Respiration ; RNA, Messenger - metabolism ; Rodents ; Roles ; Sulfhydryl Compounds - metabolism
É parte de: Oxidative medicine and cellular longevity, 2016-01, Vol.2016, p.6738701-10
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: José L. Quiles
Descrição: NADPH oxidases (NOX) are important sources of reactive oxygen species (ROS) in skeletal muscle, being involved in excitation-contraction coupling. Thus, we aimed to investigate if NOX activity and expression in skeletal muscle are fiber type specific and the possible contribution of this difference to cellular oxidative stress. Oxygen consumption rate, NOX activity and mRNA levels, and the activity of catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD), as well as the reactive protein thiol levels, were measured in the soleus (SOL), red gastrocnemius (RG), and white gastrocnemius (WG) muscles of rats. RG showed higher oxygen consumption flow than SOL and WG, while SOL had higher oxygen consumption than WG. SOL showed higher NOX activity, as well as NOX2 and NOX4 mRNA levels, antioxidant enzymatic activities, and reactive protein thiol contents when compared to WG and RG. NOX activity and NOX4 mRNA levels as well as antioxidant enzymatic activities were higher in RG than in WG. Physical exercise increased NOX activity in SOL and RG, specifically NOX2 mRNA levels in RG and NOX4 mRNA levels in SOL. In conclusion, we demonstrated that NOX activity and expression differ according to the skeletal muscle fiber type, as well as antioxidant defense.
Editor: United States: Hindawi Publishing Corporation
Idioma: Inglês

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Differential Expression of NADPH Oxidases Depends on Skeletal Muscle Fiber Type in Rats

United States: Hindawi Publishing Corporation

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