skip to main content
Visitante
Meu Espaço
Minha Conta
Sair
Identificação
This feature requires javascript
Tags
Revistas Eletrônicas (eJournals)
Livros Eletrônicos (eBooks)
Bases de Dados
Bibliotecas USP
Ajuda
Ajuda
Idioma:
Inglês
Espanhol
Português
This feature required javascript
This feature requires javascript
Primo Search
Busca Geral
Busca Geral
Acervo Físico
Acervo Físico
Produção Intelectual da USP
Produção USP
Search For:
Clear Search Box
Search in:
Busca Geral
Or select another collection:
Search in:
Busca Geral
Busca Avançada
Busca por Índices
This feature requires javascript
This feature requires javascript
Macrophage signaling in HIV-1 infection
Herbein, Georges ; Gras, Gabriel ; Khan, Kashif Aziz ; Abbas, Wasim
Retrovirology, 2010-04, Vol.7 (1), p.34-34, Article 34
[Periódico revisado por pares]
England: BioMed Central Ltd
Texto completo disponível
Citações
Citado por
Exibir Online
Detalhes
Resenhas & Tags
Mais Opções
Nº de Citações
This feature requires javascript
Enviar para
Adicionar ao Meu Espaço
Remover do Meu Espaço
E-mail (máximo 30 registros por vez)
Imprimir
Link permanente
Referência
EasyBib
EndNote
RefWorks
del.icio.us
Exportar RIS
Exportar BibTeX
This feature requires javascript
Título:
Macrophage signaling in HIV-1 infection
Autor:
Herbein, Georges
;
Gras, Gabriel
;
Khan, Kashif Aziz
;
Abbas, Wasim
Assuntos:
Acquired immune deficiency syndrome
;
AIDS
;
Apoptosis
;
Binding sites
;
Cellular signal transduction
;
Chemokines
;
Disease
;
Genetic aspects
;
Genetic transcription
;
Health aspects
;
HIV
;
HIV Envelope Protein gp120
;
HIV Envelope Protein gp120 - immunology
;
HIV Envelope Protein gp120 - physiology
;
HIV infection
;
HIV Infections
;
HIV Infections - immunology
;
HIV Infections - virology
;
HIV-1
;
HIV-1 - immunology
;
HIV-1 - pathogenicity
;
Human health and pathology
;
Human immunodeficiency virus
;
Humans
;
Immune system
;
Infectious diseases
;
Life Sciences
;
Lymphocytes
;
Macrophage Activation
;
Macrophages
;
Macrophages - immunology
;
nef Gene Products, Human Immunodeficiency Virus
;
nef Gene Products, Human Immunodeficiency Virus - immunology
;
nef Gene Products, Human Immunodeficiency Virus - physiology
;
Pathogenesis
;
Phosphorylation
;
Proteins
;
Review
;
Risk factors
;
Signal Transduction
;
tat Gene Products, Human Immunodeficiency Virus
;
tat Gene Products, Human Immunodeficiency Virus - immunology
;
tat Gene Products, Human Immunodeficiency Virus - physiology
;
Viral proteins
;
Virulence Factors
;
Virulence Factors - immunology
;
Virulence Factors - physiology
;
vpr Gene Products, Human Immunodeficiency Virus
;
vpr Gene Products, Human Immunodeficiency Virus - immunology
;
vpr Gene Products, Human Immunodeficiency Virus - physiology
É parte de:
Retrovirology, 2010-04, Vol.7 (1), p.34-34, Article 34
Notas:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição:
The human immunodeficiency virus-1 (HIV-1) is a member of the lentivirus genus. The virus does not rely exclusively on the host cell machinery, but also on viral proteins that act as molecular switches during the viral life cycle which play significant functions in viral pathogenesis, notably by modulating cell signaling. The role of HIV-1 proteins (Nef, Tat, Vpr, and gp120) in modulating macrophage signaling has been recently unveiled. Accessory, regulatory, and structural HIV-1 proteins interact with signaling pathways in infected macrophages. In addition, exogenous Nef, Tat, Vpr, and gp120 proteins have been detected in the serum of HIV-1 infected patients. Possibly, these proteins are released by infected/apoptotic cells. Exogenous accessory regulatory HIV-1 proteins are able to enter macrophages and modulate cellular machineries including those that affect viral transcription. Furthermore HIV-1 proteins, e.g., gp120, may exert their effects by interacting with cell surface membrane receptors, especially chemokine co-receptors. By activating the signaling pathways such as NF-kappaB, MAP kinase (MAPK) and JAK/STAT, HIV-1 proteins promote viral replication by stimulating transcription from the long terminal repeat (LTR) in infected macrophages; they are also involved in macrophage-mediated bystander T cell apoptosis. The role of HIV-1 proteins in the modulation of macrophage signaling will be discussed in regard to the formation of viral reservoirs and macrophage-mediated T cell apoptosis during HIV-1 infection.
Editor:
England: BioMed Central Ltd
Idioma:
Inglês
Links
View this record in MEDLINE/PubMed
View record in HAL
This feature requires javascript
This feature requires javascript
Voltar para lista de resultados
Anterior
Resultado
8
Avançar
This feature requires javascript
This feature requires javascript
Buscando em bases de dados remotas. Favor aguardar.
Buscando por
em
scope:(USP_PRODUCAO),scope:(USP_EBOOKS),scope:("PRIMO"),scope:(USP),scope:(USP_EREVISTAS),scope:(USP_FISICO),primo_central_multiple_fe
Mostrar o que foi encontrado até o momento
This feature requires javascript
This feature requires javascript