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Nitric oxide, cholesterol oxides and endothelium-dependent vasodilation in plasma of patients with essential hypertension

Moriel, P ; Sevanian, A ; Ajzen, S ; Zanella, M T ; Plavnik, F L ; Rubbo, H ; Abdalla, D S P

Brazilian journal of medical and biological research, 2002-11, Vol.35 (11), p.1301-1309 [Periódico revisado por pares]

Brazil: Associação Brasileira de Divulgação Científica

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Título:
Nitric oxide, cholesterol oxides and endothelium-dependent vasodilation in plasma of patients with essential hypertension
Autor: Moriel, P ; Sevanian, A ; Ajzen, S ; Zanella, M T ; Plavnik, F L ; Rubbo, H ; Abdalla, D S P
Assuntos: Adult ; Aged ; Biological Availability ; BIOLOGY ; Case-Control Studies ; Cholesterol, LDL - chemistry ; Cholesterol, LDL - metabolism ; Chromatography ; Endothelin-1 ; Endothelin-1 - blood ; Endothelium, Vascular - physiopathology ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Hypertension - blood ; Hypertension - physiopathology ; Lipid peroxidation ; Lipid Peroxidation - physiology ; Male ; MEDICINE, RESEARCH & EXPERIMENTAL ; Middle Aged ; Nitrate ; Nitric Oxide - blood ; Nitrotyrosine ; Oxidative Stress - physiology ; Oxidized LDL ; S-nitrosothiols ; Vasodilation - physiology
É parte de: Brazilian journal of medical and biological research, 2002-11, Vol.35 (11), p.1301-1309
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The objective of the present study was to identify disturbances of nitric oxide radical (.NO) metabolism and the formation of cholesterol oxidation products in human essential hypertension. The concentrations of.NO derivatives (nitrite, nitrate, S-nitrosothiols and nitrotyrosine), water and lipid-soluble antioxidants and cholesterol oxides were measured in plasma of 11 patients with mild essential hypertension (H: 57.8 +/- 9.7 years; blood pressure, 148.3 +/- 24.8/90.8 +/- 10.2 mmHg) and in 11 healthy subjects (N: 48.4 +/- 7.0 years; blood pressure, 119.4 +/- 9.4/75.0 +/- 8.0 mmHg). Nitrite, nitrate and S-nitrosothiols were measured by chemiluminescence and nitrotyrosine was determined by ELISA. Antioxidants were determined by reverse-phase HPLC and cholesterol oxides by gas chromatography. Hypertensive patients had reduced endothelium-dependent vasodilation in response to reactive hyperemia (H: 9.3 and N: 15.1% increase of diameter 90 s after hyperemia), and lower levels of ascorbate (H: 29.2 +/- 26.0, N: 54.2 +/- 24.9 micro M), urate (H: 108.5 +/- 18.9, N: 156.4 +/- 26.3 micro M), beta-carotene (H: 1.1 +/- 0.8, N: 2.5 +/- 1.2 nmol/mg cholesterol), and lycopene (H: 0.4 +/- 0.2, N: 0.7 +/- 0.2 nmol/mg cholesterol), in plasma, compared to normotensive subjects. The content of 7-ketocholesterol, 5alpha-cholestane-3beta,5,6beta-triol and 5,6alpha-epoxy-5alpha-cholestan-3alpha-ol in LDL, and the concentration of endothelin-1 (H: 0.9 +/- 0.2, N: 0.7 +/- 0.1 ng/ml) in plasma were increased in hypertensive patients. No differences were found for.NO derivatives between groups. These data suggest that an increase in cholesterol oxidation is associated with endothelium dysfunction in essential hypertension and oxidative stress, although.NO metabolite levels in plasma are not modified in the presence of elevated cholesterol oxides.
Editor: Brazil: Associação Brasileira de Divulgação Científica
Idioma: Inglês;Português

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Nitric oxide, cholesterol oxides and endothelium-dependent vasodilation in plasma of patients with essential hypertension

Moriel, P ; Sevanian, A ; Ajzen, S ; Zanella, M T ; Plavnik, F L ; Rubbo, H ; Abdalla, D S P

Brazil: Associação Brasileira de Divulgação Científica

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