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Valorization of Kiwiberry Leaves Recovered by Ultrasound-Assisted Extraction for Skin Application: A Response Surface Methodology Approach

Silva, Ana Margarida ; Pinto, Diana ; Moreira, Manuela M ; Costa, Paulo C ; Delerue-Matos, Cristina ; Rodrigues, Francisca

Antioxidants, 2022-04, Vol.11 (4), p.763 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Valorization of Kiwiberry Leaves Recovered by Ultrasound-Assisted Extraction for Skin Application: A Response Surface Methodology Approach
Autor: Silva, Ana Margarida ; Pinto, Diana ; Moreira, Manuela M ; Costa, Paulo C ; Delerue-Matos, Cristina ; Rodrigues, Francisca
Assuntos: Acids ; Actinidia arguta ; Actinidia arguta leaves ; Antioxidants ; By products ; Calibration ; cell viability ; Experiments ; Ferrous sulfate ; Fibroblasts ; Free radicals ; Gallic acid ; Hypochlorous acid ; Keratinocytes ; Phenolic compounds ; Polyphenols ; response surface methodology ; Skin ; Ultrasonic imaging ; Ultrasound ; ultrasound-assisted extraction
É parte de: Antioxidants, 2022-04, Vol.11 (4), p.763
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: This study aims to evaluate the optimal ultrasound-assisted extraction (UAE) conditions of antioxidants polyphenols from (Siebold & Zucc.) Planch. Ex Miq. (kiwiberry) leaves using a response surface methodology (RSM). The effects of solid:liquid ratio (2.5-10.0% / ), time (20-60 min), and intensity (30-70 W/m ) on the total phenolic content (TPC) and antioxidant/antiradical activities were investigated. The optimal UAE conditions were achieved using a solid:liquid ratio of 10% ( / ) and an ultrasonic intensity of 30 W/m for 31.11 min. The results demonstrated that the optimal extract showed a high TPC (97.50 mg of gallic acid equivalents (GAE)/g dw) and antioxidant/antiradical activity (IC = 249.46 µg/mL for ABTS assay; IC = 547.34 µg/mL for DPPH assay; 1440.13 µmol of ferrous sulfate equivalents (FSE)/g dw for ferric reducing antioxidant power (FRAP)) as well as a good capacity to scavenge superoxide and hypochlorous acid (respectively, IC = 220.13 μg/mL and IC =10.26 μg/mL), which may be related with the 28 phenolic compounds quantified. The in vitro cell assay demonstrated that the optimal extract did not decrease the keratinocytes' (HaCaT) viability, while the fibroblasts' (HFF-1) viability was greater than 70.63% (1000 µg/mL). This study emphasizes the great potential of kiwiberry leaves extracted by UAE for skin application.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Valorization of Kiwiberry Leaves Recovered by Ultrasound-Assisted Extraction for Skin Application: A Response Surface Methodology Approach

Silva, Ana Margarida ; Pinto, Diana ; Moreira, Manuela M ; Costa, Paulo C ; Delerue-Matos, Cristina ; Rodrigues, Francisca

Switzerland: MDPI AG

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