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Relationship between Suppression of E6 and E7 Virus Oncogenes and Expression of Apoptosis and Cell Cycle Genes in Cervical Cancer Culture

Khokhlova, E. V ; Shkoporov, A. N ; Volodin, N. N ; Efimov, B. A ; Pavlov, K. A ; Kafarskaia, L. I

Bulletin of experimental biology and medicine, 2010-07, Vol.149 (1), p.73-77 [Periódico revisado por pares]

Boston: Boston : Springer US

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Título:
Relationship between Suppression of E6 and E7 Virus Oncogenes and Expression of Apoptosis and Cell Cycle Genes in Cervical Cancer Culture
Autor: Khokhlova, E. V ; Shkoporov, A. N ; Volodin, N. N ; Efimov, B. A ; Pavlov, K. A ; Kafarskaia, L. I
Assuntos: Apoptosis ; Apoptosis - drug effects ; Apoptosis - genetics ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; cdc25 Phosphatases - metabolism ; Cell Biology ; Cell cycle ; Cell Cycle Proteins - metabolism ; Cervical cancer ; Cyclin-Dependent Kinase Inhibitor p21 - metabolism ; DNA ; DNA microarrays ; DNA Primers - genetics ; DNA-Binding Proteins - metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Viral - drug effects ; Genes ; Genes, cdc - drug effects ; Genetic aspects ; Genetic transcription ; GRB2 Adaptor Protein - metabolism ; HeLa Cells ; human papilloma viruses ; Humans ; Infection ; Internal Medicine ; Laboratory Medicine ; Microarray Analysis ; Microtubule-Associated Proteins - metabolism ; Oncogene Proteins, Viral - metabolism ; Oncology ; Papillomavirus infections ; Pathology ; Polo-Like Kinase 1 ; Protein Serine-Threonine Kinases - metabolism ; Proto-Oncogene Proteins - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; RNA ; RNA interference ; RNA, Small Interfering - pharmacology ; small interfering RNA ; viral Oncogenes
É parte de: Bulletin of experimental biology and medicine, 2010-07, Vol.149 (1), p.73-77
Notas: http://dx.doi.org/10.1007/s10517-010-0879-2
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Descrição: The effects of short interfering RNA suppressing the expression of E6 and E7 human papilloma virus (type 18) on the expression of apoptosis and cell cycle genes were studied in HeLa cells. Changes in the transcription profiles were evaluated using DNA microarray and real-time reverse-transcription PCR. Cell transfection with anti-E6 and anti-E7 short interfering RNA moderately reduced the expression of mRNA for CDC25C, GRB2, GTSE1, and PLK1 genes and induced expression of CDKN1A (p21CIP) gene mRNA. In addition, culture proliferation was inhibited and morphological changes characteristic of differentiation and cell aging developed.
Editor: Boston: Boston : Springer US
Idioma: Inglês

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Relationship between Suppression of E6 and E7 Virus Oncogenes and Expression of Apoptosis and Cell Cycle Genes in Cervical Cancer Culture

Khokhlova, E. V ; Shkoporov, A. N ; Volodin, N. N ; Efimov, B. A ; Pavlov, K. A ; Kafarskaia, L. I

Boston: Boston : Springer US

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