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Concepts of extracellular matrix remodelling in tumour progression and metastasis

Winkler, Juliane ; Abisoye-Ogunniyan, Abisola ; Metcalf, Kevin J. ; Werb, Zena

Nature communications, 2020-10, Vol.11 (1), p.1-19, Article 5120 [Periódico revisado por pares]

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Título:
Concepts of extracellular matrix remodelling in tumour progression and metastasis
Autor: Winkler, Juliane ; Abisoye-Ogunniyan, Abisola ; Metcalf, Kevin J. ; Werb, Zena
Assuntos: Review
É parte de: Nature communications, 2020-10, Vol.11 (1), p.1-19, Article 5120
Descrição: Abstract Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM. These tumour-driven changes support tumour growth, increase migration of tumour cells, and remodel the ECM in distant organs to allow for metastatic progression. A better understanding of the underlying mechanisms of tumourigenic ECM remodelling is crucial for developing therapeutic treatments for patients.
Editor: London: Nature Publishing Group UK
Idioma: Inglês

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