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Are the severe injuries of cutaneous leishmaniasis caused by an exacerbated Th1 response?

NICODEMO, A. C. ; AMATO, V. S. ; MIRANDA, A. M. ; FLOETER-WINTER, L. M. F. ; ZAMPIERI, R. A. ; FERNADES, E. R. ; DUARTE, M. I. S.

Parasite immunology, 2012-08, Vol.34 (8-9), p.440-443 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Are the severe injuries of cutaneous leishmaniasis caused by an exacerbated Th1 response?
Autor: NICODEMO, A. C. ; AMATO, V. S. ; MIRANDA, A. M. ; FLOETER-WINTER, L. M. F. ; ZAMPIERI, R. A. ; FERNADES, E. R. ; DUARTE, M. I. S.
Assuntos: Adult ; cutaneous leishmaniasis ; Cytokines - immunology ; Female ; Humans ; immune response ; Leg - pathology ; Leishmaniasis, Cutaneous - immunology ; Leishmaniasis, Cutaneous - pathology ; Skin - immunology ; Skin - pathology ; Th1 Cells - immunology ; Toll-Like Receptor 3 - biosynthesis
É parte de: Parasite immunology, 2012-08, Vol.34 (8-9), p.440-443
Notas: ark:/67375/WNG-FXZLJBFW-3
ArticleID:PIM1372
istex:652DFC701BE997FA5E4A1357A8C5E7C38D8E56EE
Disclosures: None.
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ObjectType-Case Study-2
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Descrição: Summary American tegumentary leishmaniasis (ATL) is a disease whose clinical features are strongly related to the type of immune response it induces. Herein we report an atypical presentation of cutaneous leishmaniasis in a woman with a severe and extensive sore located in her leg, and we describe the differences between the usual local immune response in ATL and the local immune response in this patient. We observed an intense inflammatory response characterized by Th1 cells and cytokines with conspicuous expression of Toll‐like receptor 3 (TLR‐3). Few parasites were present, but there was an extensive tissue damage. We also discuss the immunological factors that could be related to the atypical presentation.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Are the severe injuries of cutaneous leishmaniasis caused by an exacerbated Th1 response?

NICODEMO, A. C. ; AMATO, V. S. ; MIRANDA, A. M. ; FLOETER-WINTER, L. M. F. ; ZAMPIERI, R. A. ; FERNADES, E. R. ; DUARTE, M. I. S.

Oxford, UK: Blackwell Publishing Ltd

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