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Myocardial ischaemia reperfusion injury and cardioprotection in the presence of sensory neuropathy: Therapeutic options

Bencsik, Péter ; Gömöri, Kamilla ; Szabados, Tamara ; Sántha, Péter ; Helyes, Zsuzsanna ; Jancsó, Gábor ; Ferdinandy, Péter ; Görbe, Anikó

British journal of pharmacology, 2020-12, Vol.177 (23), p.5336-5356 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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  • Título:
    Myocardial ischaemia reperfusion injury and cardioprotection in the presence of sensory neuropathy: Therapeutic options
  • Autor: Bencsik, Péter ; Gömöri, Kamilla ; Szabados, Tamara ; Sántha, Péter ; Helyes, Zsuzsanna ; Jancsó, Gábor ; Ferdinandy, Péter ; Görbe, Anikó
  • Assuntos: Cardiac conditioning ; Cardiovascular diseases ; Congestive heart failure ; Coronary artery disease ; Ischemia ; Myocardial infarction ; Neuropathy ; Reperfusion ; Review ; Risk factors ; Signal transduction
  • É parte de: British journal of pharmacology, 2020-12, Vol.177 (23), p.5336-5356
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: During the last decades, mortality from acute myocardial infarction has been dramatically reduced. However, the incidence of post‐infarction heart failure is still increasing. Cardioprotection by ischaemic conditioning had been discovered more than three decades ago. Its clinical translation, however, is still an unmet need. This is mainly due to the disrupted cardioprotective signalling pathways in the presence of different cardiovascular risk factors, co‐morbidities and the medication being taken. Sensory neuropathy is one of the co‐morbidities that has been shown to interfere with cardioprotection. In the present review, we summarize the diverse aetiology of sensory neuropathies and the mechanisms by which these neuropathies may interfere with ischaemic heart disease and cardioprotective signalling. Finally, we suggest future therapeutic options targeting both ischaemic heart and sensory neuropathy simultaneously. LINKED ARTICLES This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.23/issuetoc
  • Editor: England: Blackwell Publishing Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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