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Role of thymidine phosphorylase and dihydropyrimidine dehydrogenase in tumour progression and sensitivity to doxifluridine in gastric cancer patients

Terashima, M ; Fujiwara, H ; Takagane, A ; Abe, K ; Araya, M ; Irinoda, T ; Yonezawa, H ; Nakaya, T ; Oyama, K ; Takahashi, M ; Saito, K

European journal of cancer (1990), 2002-12, Vol.38 (18), p.2375-2381 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Título:
Role of thymidine phosphorylase and dihydropyrimidine dehydrogenase in tumour progression and sensitivity to doxifluridine in gastric cancer patients
Autor: Terashima, M ; Fujiwara, H ; Takagane, A ; Abe, K ; Araya, M ; Irinoda, T ; Yonezawa, H ; Nakaya, T ; Oyama, K ; Takahashi, M ; Saito, K
Assuntos: Adult ; Aged ; Aged, 80 and over ; Antimetabolites, Antineoplastic - therapeutic use ; Antineoplastic agents ; Biological and medical sciences ; Chemotherapy ; Dihydropyrimidine dehydrogenase ; Dihydrouracil Dehydrogenase (NADP) ; Disease Progression ; Doxyfluridine ; Drug sensitivity testing ; Enzyme-Linked Immunosorbent Assay ; Female ; Floxuridine - therapeutic use ; Gastric cancer ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Middle Aged ; Oxidoreductases - physiology ; Pharmacology. Drug treatments ; Stomach Neoplasms - drug therapy ; Stomach Neoplasms - enzymology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Analysis ; Thymidine phosphorylase ; Thymidine Phosphorylase - physiology ; Tumors
É parte de: European journal of cancer (1990), 2002-12, Vol.38 (18), p.2375-2381
Descrição: This study was designed to investigate the role of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) on tumour progression and sensitivity to 5′-deoxy-5-fluorouridine (5′-DFUR). Tumour tissue was obtained from surgically resected samples from 93 patients with primary gastric cancer. Tumour TP and DPD expression levels were determined by the enzyme-linked immunosorbent assay (ELISA) system and compared with several clinicopathological factors and in vitro sensitivity to 5′-DFUR. DPD showed no correlation with any clinicopathological factors. However, the TP level was significantly correlated with the depth of tumour, lymphatic invasion and venous invasion. In comparison with 5′-DFUR sensitivity, there was a weak inverse correlation between the DPD level and the sensitivity to 5′-DFUR (rs=−0.361). Furthermore, the TP/DPD ratio showed a significant correlation with 5′-DFUR sensitivity (rs=0.634). In a subgroup of patients with postoperative 5′-DFUR administration, the survival rate was significantly better in patients with a high TP/DPD ratio (n=8) than in those with low TP/DPD ratio (n=14) (P=0.0140). These results suggest that sensitivity to 5′-DFUR is predictable by measurement of both TP and DPD levels.
Editor: Oxford: Elsevier Ltd
Idioma: Inglês

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Role of thymidine phosphorylase and dihydropyrimidine dehydrogenase in tumour progression and sensitivity to doxifluridine in gastric cancer patients

Terashima, M ; Fujiwara, H ; Takagane, A ; Abe, K ; Araya, M ; Irinoda, T ; Yonezawa, H ; Nakaya, T ; Oyama, K ; Takahashi, M ; Saito, K

Oxford: Elsevier Ltd

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