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Long–term survival in trial of medium–titre Edmonston–Zagreb measles vaccine in Guinea–Bissau: five–year follow–up

Aaby, P. ; Lisse, I. M. ; Whittle, H. ; Knudsen, K. ; Thaarup, J. ; Poulsen, A. ; Sodemann, M. ; Jakobsen, M. ; Brink, L. ; Gansted, U. ; Permin, A. ; Jensen, T. G. ; Andersen, H. ; da Silva, M. C.

Epidemiology and infection, 1994-04, Vol.112 (2), p.413-420 [Periódico revisado por pares]

Cambridge, UK: Cambridge University Press

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Título:
Long–term survival in trial of medium–titre Edmonston–Zagreb measles vaccine in Guinea–Bissau: five–year follow–up
Autor: Aaby, P. ; Lisse, I. M. ; Whittle, H. ; Knudsen, K. ; Thaarup, J. ; Poulsen, A. ; Sodemann, M. ; Jakobsen, M. ; Brink, L. ; Gansted, U. ; Permin, A. ; Jensen, T. G. ; Andersen, H. ; da Silva, M. C.
Assuntos: Age Factors ; Antibodies ; Biological and medical sciences ; Body Height ; Child growth ; Child, Preschool ; Children ; Female ; Follow-Up Studies ; Growth Disorders - chemically induced ; Growth Disorders - diagnosis ; Growth Disorders - epidemiology ; Guinea-Bissau - epidemiology ; Humans ; Immune Tolerance - drug effects ; Immunization ; Immunization Schedule ; Infant ; Leukocyte Count ; Malaria - blood ; Malaria - epidemiology ; Malaria - parasitology ; Male ; Measles ; Measles Vaccine - adverse effects ; Measles Vaccine - classification ; Measles Vaccine - immunology ; Measles vaccines ; Medical research ; Medical sciences ; Mortality ; Population ; Prevention and actions ; Proportional Hazards Models ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Specific populations (family, woman, child, elderly...) ; Survival Rate ; T lymphocytes ; T-Lymphocyte Subsets ; Vaccination
É parte de: Epidemiology and infection, 1994-04, Vol.112 (2), p.413-420
Notas: PII:S0950268800057836
ArticleID:05783
istex:6FF086B325371824AE2B3CDC247C099BAFB44B18
ark:/67375/6GQ-48Q02ZVR-N
Peter Aaby, Epidemiology Research Unit, Artillerivej 5, 2300 Copenhagen S, Denmark.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-News-3
Descrição: A trial of protective efficacy which compared medium–titre Edmonston-Zagreb (EZ) measles vaccine (104.6 p.f.u.) from the age of 4 months with the standard Schwarz (SW) measles vaccine given from the age of 9 months was started in an urban community in Guinea-Bissau in 1985. Because trials of high–titre measles vaccine have found increased mortality among female recipients, we examined whether EZ medium–titre vaccine was associated with any long-term impact on mortality, suppression of T–cells, or growth. The mortality rate ratio over 5 years of follow–up was 1.12 for EZ children compared with children in the standard group (P = 0.63). Seventy–five percent of the children still residing in the area at 5 years of age took part in an immunological and anthropometric examination. There was no difference in T–cell subsets between the two groups. There was no difference in mid–upper–arm circumference, but EZ children were significantly shorter than the children in the standard group. In conclusion, medium–titre EZ was not associated with reduced survival or persistent immunosuppression.
Editor: Cambridge, UK: Cambridge University Press
Idioma: Inglês

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Long–term survival in trial of medium–titre Edmonston–Zagreb measles vaccine in Guinea–Bissau: five–year follow–up

Aaby, P. ; Lisse, I. M. ; Whittle, H. ; Knudsen, K. ; Thaarup, J. ; Poulsen, A. ; Sodemann, M. ; Jakobsen, M. ; Brink, L. ; Gansted, U. ; Permin, A. ; Jensen, T. G. ; Andersen, H. ; da Silva, M. C.

Cambridge, UK: Cambridge University Press

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