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Personalized Perioperative Multi-scale, Multi-physics Heart Simulation of Double Outlet Right Ventricle

Kariya, Taro ; Washio, Takumi ; Okada, Jun-ichi ; Nakagawa, Machiko ; Watanabe, Masahiro ; Kadooka, Yoshimasa ; Sano, Shunji ; Nagai, Ryozo ; Sugiura, Seiryo ; Hisada, Toshiaki

Annals of biomedical engineering, 2020-06, Vol.48 (6), p.1740-1750 [Periódico revisado por pares]

Cham: Springer International Publishing

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Título:
Personalized Perioperative Multi-scale, Multi-physics Heart Simulation of Double Outlet Right Ventricle
Autor: Kariya, Taro ; Washio, Takumi ; Okada, Jun-ichi ; Nakagawa, Machiko ; Watanabe, Masahiro ; Kadooka, Yoshimasa ; Sano, Shunji ; Nagai, Ryozo ; Sugiura, Seiryo ; Hisada, Toshiaki
Assuntos: Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Biophysics ; Cardiovascular disease ; Cardiovascular diseases ; Classical Mechanics ; Computed tomography ; Computer simulation ; Congenital diseases ; Coronary artery disease ; Decision making ; Double Outlet Right Ventricle - diagnostic imaging ; Double Outlet Right Ventricle - physiopathology ; EKG ; Electrocardiography ; Electrophysiology ; Heart ; Heart diseases ; Hemodynamics ; Humans ; Mathematical models ; Medical treatment ; Models, Cardiovascular ; Molecular modelling ; Original Article ; Pathophysiology ; Patient-Specific Modeling ; Patients ; Perioperative Period ; Surgery ; Three dimensional models ; Tomography, X-Ray Computed ; Torso ; Ventricle
É parte de: Annals of biomedical engineering, 2020-06, Vol.48 (6), p.1740-1750
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SourceType-Scholarly Journals-1
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Descrição: For treatment of complex congenital heart disease, computer simulation using a three-dimensional heart model may help to improve outcomes by enabling detailed preoperative evaluations. However, no highly integrated model that accurately reproduces a patient’s pathophysiology, which is required for this simulation has been reported. We modelled a case of complex congenital heart disease, double outlet right ventricle with ventricular septal defect and atrial septal defect. From preoperative computed tomography images, finite element meshes of the heart and torso were created, and cell model of cardiac electrophysiology and sarcomere dynamics was implemented. The parameter values of the heart model were adjusted to reproduce the patient’s electrocardiogram and haemodynamics recorded preoperatively. Two options of in silico surgery were performed using this heart model, and the resulting changes in performance were examined. Preoperative and postoperative simulations showed good agreement with clinical records including haemodynamics and measured oxyhaemoglobin saturations. The use of a detailed sarcomere model also enabled comparison of energetic efficiency between the two surgical options. A novel in silico model of congenital heart disease that integrates molecular models of cardiac function successfully reproduces the observed pathophysiology. The simulation of postoperative state by in silico surgeries can help guide clinical decision-making.
Editor: Cham: Springer International Publishing
Idioma: Inglês

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Personalized Perioperative Multi-scale, Multi-physics Heart Simulation of Double Outlet Right Ventricle

Kariya, Taro ; Washio, Takumi ; Okada, Jun-ichi ; Nakagawa, Machiko ; Watanabe, Masahiro ; Kadooka, Yoshimasa ; Sano, Shunji ; Nagai, Ryozo ; Sugiura, Seiryo ; Hisada, Toshiaki

Cham: Springer International Publishing

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