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1-Deoxynojirimycin containing Morus alba leaf-based food modulates the gut microbiome and expression of genes related to obesity

Jaiswal, Varun ; Lee, Mi-Jin ; Chun, Ju Lan ; Park, Miey ; Lee, Hae-Jeung

BMC veterinary research, 2024-04, Vol.20 (1), p.133-133, Article 133 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
1-Deoxynojirimycin containing Morus alba leaf-based food modulates the gut microbiome and expression of genes related to obesity
Autor: Jaiswal, Varun ; Lee, Mi-Jin ; Chun, Ju Lan ; Park, Miey ; Lee, Hae-Jeung
Assuntos: 1-Deoxynojirimycin - pharmacology ; Animals ; Biological diversity ; Blood ; Body weight ; Care and treatment ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - veterinary ; Diagnosis ; Diseases ; Dog Diseases ; Dogs ; EGR-1 protein ; Feeds ; Food ; Football (College) ; Gastrointestinal Microbiome ; Genes ; Genetic aspects ; Health aspects ; Humans ; Intestinal microflora ; Leaves ; Medicated feeds ; Metabolic Diseases - veterinary ; Metabolic disorders ; Metabolites ; Microbiome ; Microbiomes ; Microbiota ; Microbiota (Symbiotic organisms) ; Morus ; Morus alba ; Natural products ; Obesity ; Obesity - drug therapy ; Obesity - veterinary ; Pathways ; Plant Extracts - pharmacology ; Plant Leaves ; Taxonomy ; Transcriptome ; Transcriptomes
É parte de: BMC veterinary research, 2024-04, Vol.20 (1), p.133-133, Article 133
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Obesity is a serious disease with an alarmingly high incidence that can lead to other complications in both humans and dogs. Similar to humans, obesity can cause metabolic diseases such as diabetes in dogs. Natural products may be the preferred intervention for metabolic diseases such as obesity. The compound 1-deoxynojirimycin, present in Morus leaves and other sources has antiobesity effects. The possible antiobesity effect of 1-deoxynojirimycin containing Morus alba leaf-based food was studied in healthy companion dogs (n = 46) visiting the veterinary clinic without a history of diseases. Body weight, body condition score (BCS), blood-related parameters, and other vital parameters of the dogs were studied. Whole-transcriptome of blood and gut microbiome analysis was also carried out to investigate the possible mechanisms of action and role of changes in the gut microbiome due to treatment. After 90 days of treatment, a significant antiobesity effect of the treatment food was observed through the reduction of weight, BCS, and blood-related parameters. A whole-transcriptome study revealed differentially expressed target genes important in obesity and diabetes-related pathways such as MLXIPL, CREB3L1, EGR1, ACTA2, SERPINE1, NOTCH3, and CXCL8. Gut microbiome analysis also revealed a significant difference in alpha and beta-diversity parameters in the treatment group. Similarly, the microbiota known for their health-promoting effects such as Lactobacillus ruminis, and Weissella hellenica were abundant (increased) in the treatment group. The predicted functional pathways related to obesity were also differentially abundant between groups. 1-Deoxynojirimycin-containing treatment food have been shown to significantly improve obesity. The identified genes, pathways, and gut microbiome-related results may be pursued in further studies to develop 1-deoxynojirimycin-based products as candidates against obesity.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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1-Deoxynojirimycin containing Morus alba leaf-based food modulates the gut microbiome and expression of genes related to obesity

Jaiswal, Varun ; Lee, Mi-Jin ; Chun, Ju Lan ; Park, Miey ; Lee, Hae-Jeung

England: BioMed Central Ltd

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