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Acute rhabdomyolysis and delayed pericardial effusion in an Italian patient with Ebola virus disease: a case report

Nicastri, Emanuele ; Brucato, Antonio ; Petrosillo, Nicola ; Biava, Gianluigi ; Uyeki, Timothy M ; Ippolito, Giuseppe

BMC infectious diseases, 2017-08, Vol.17 (1), p.597-597, Article 597 [Periódico revisado por pares]

England: BioMed Central Ltd

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Acute rhabdomyolysis and delayed pericardial effusion in an Italian patient with Ebola virus disease: a case report
Autor: Nicastri, Emanuele ; Brucato, Antonio ; Petrosillo, Nicola ; Biava, Gianluigi ; Uyeki, Timothy M ; Ippolito, Giuseppe
Assuntos: Adrenal Cortex Hormones - therapeutic use ; Adult ; Amides - therapeutic use ; Antibodies, Monoclonal - therapeutic use ; Care and treatment ; Case Report ; Case reports ; Case studies ; Complications and side effects ; Corticoids ; Corticosteroids ; Diagnosis ; Disease ; Drug dosages ; Ebola virus ; Ebola Virus Disease ; Ebola virus infections ; Ebolavirus - immunology ; Ebolavirus - pathogenicity ; Effusion ; Epidemics ; Health care ; Health Personnel ; Hemorrhagic Fever, Ebola - complications ; Hemorrhagic Fever, Ebola - drug therapy ; Humans ; Illnesses ; Indomethacin ; Indomethacin - therapeutic use ; Infections ; Intensive care ; Intravenous administration ; Italy ; Male ; Medical personnel ; Monoclonal antibodies ; Patients ; Pericardial effusion ; Pericardial Effusion - drug therapy ; Pericardial Effusion - etiology ; Pericardial Effusion - virology ; Plasma ; Pyrazines - therapeutic use ; Recovery ; Rhabdomyolysis ; Rhabdomyolysis - drug therapy ; Rhabdomyolysis - etiology ; Rhabdomyolysis - virology ; Risk factors ; Sierra Leone ; Viral diseases ; Viruses
É parte de: BMC infectious diseases, 2017-08, Vol.17 (1), p.597-597, Article 597
Notas: ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
Descrição: During the 2013-2016 West Africa Ebola virus disease (EVD) epidemic, some EVD patients, mostly health care workers, were evacuated to Europe and the USA. In May 2015, a 37-year old male nurse contracted Ebola virus disease in Sierra Leone. After Ebola virus detection in plasma, he was medically-evacuated to Italy. At admission, rhabdomyolysis was clinically and laboratory-diagnosed and was treated with aggressive hydration, oral favipiravir and intravenous investigational monoclonal antibodies against Ebola virus. The recovery clinical phase was complicated by a febrile thrombocytopenic syndrome with pericardial effusion treated with corticosteroids for 10 days and indomethacin for 2 months. No evidence of recurrence is reported. A febrile thrombocytopenic syndrome with pericardial effusion during the recovery phase of EVD appears to be uncommon. Clinical improvement with corticosteroid treatment suggests that an immune-mediated mechanism contributed to the pericardial effusion.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Acute rhabdomyolysis and delayed pericardial effusion in an Italian patient with Ebola virus disease: a case report

Nicastri, Emanuele ; Brucato, Antonio ; Petrosillo, Nicola ; Biava, Gianluigi ; Uyeki, Timothy M ; Ippolito, Giuseppe

England: BioMed Central Ltd

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