skip to main content
Idioma:

Respiratory Responses to Ozone Exposure. MOSES (The Multicenter Ozone Study in Older Subjects)

Arjomandi, Mehrdad ; Balmes, John R ; Frampton, Mark W ; Bromberg, Philip ; Rich, David Q ; Stark, Paul ; Alexis, Neil E ; Costantini, Maria ; Hollenbeck-Pringle, Danielle ; Dagincourt, Nicholas ; Hazucha, Milan J

American journal of respiratory and critical care medicine, 2018-05, Vol.197 (10), p.1319-1327 [Periódico revisado por pares]

United States: American Thoracic Society

Texto completo disponível

Citações Citado por
  • Título:
    Respiratory Responses to Ozone Exposure. MOSES (The Multicenter Ozone Study in Older Subjects)
  • Autor: Arjomandi, Mehrdad ; Balmes, John R ; Frampton, Mark W ; Bromberg, Philip ; Rich, David Q ; Stark, Paul ; Alexis, Neil E ; Costantini, Maria ; Hollenbeck-Pringle, Danielle ; Dagincourt, Nicholas ; Hazucha, Milan J
  • Assuntos: Biomarkers ; Cytokines ; Human subjects ; Inflammation ; Neutrophils ; Older people ; Oxidative stress
  • É parte de: American journal of respiratory and critical care medicine, 2018-05, Vol.197 (10), p.1319-1327
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Acute respiratory effects of low-level ozone exposure are not well defined in older adults. MOSES (The Multicenter Ozone Study in Older Subjects), although primarily focused on acute cardiovascular effects, provided an opportunity to assess respiratory responses to low concentrations of ozone in older healthy adults. We performed a randomized crossover, controlled exposure study of 87 healthy adults (59.9 ± 4.5 yr old; 60% female) to 0, 70, and 120 ppb ozone for 3 hours with intermittent exercise. Outcome measures included spirometry, sputum markers of airway inflammation, and plasma club cell protein-16 (CC16), a marker of airway epithelial injury. The effects of ozone exposure on these outcomes were evaluated with mixed-effect linear models. A P value less than 0.01 was chosen a priori to define statistical significance. The mean (95% confidence interval) FEV and FVC increased from preexposure values by 2.7% (2.0-3.4) and 2.1% (1.3-2.9), respectively, 15 minutes after exposure to filtered air (0 ppb). Exposure to ozone reduced these increases in a concentration-dependent manner. After 120-ppb exposure, FEV and FVC decreased by 1.7% (1.1-2.3) and 0.8% (0.3-1.3), respectively. A similar concentration-dependent pattern was still discernible 22 hours after exposure. At 4 hours after exposure, plasma CC16 increased from preexposure levels in an ozone concentration-dependent manner. Sputum neutrophils obtained 22 hours after exposure showed a marginally significant increase in a concentration-dependent manner (P = 0.012), but proinflammatory cytokines (IL-6, IL-8, and tumor necrosis factor-α) were not significantly affected. Exposure to ozone at near ambient levels induced lung function effects, airway injury, and airway inflammation in older healthy adults. Clinical trial registered with www.clinicaltrials.gov (NCT01487005).
  • Editor: United States: American Thoracic Society
  • Idioma: Inglês
Links
Voltar para lista de resultados
Ir para página anteriorAnterior Resultado  10 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.